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    Rbmxl2 RNA binding motif protein, X-linked-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 76572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbmxl2provided by MGI
    Official Full Name
    RNA binding motif protein, X-linked-like 2provided by MGI
    Primary source
    MGI:MGI:1923822
    See related
    Ensembl:ENSMUSG00000073894 AllianceGenome:MGI:1923822
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrnpg-t; 1700012H05Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human RBMXL2 (RBMX like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Rbmxl2 in Genome Data Viewer
    Location:
    7 E3; 7 56.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (106808652..106810123)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (107209445..107210916)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 14 Neighboring gene olfactory receptor family 2 subfamily D member 36 Neighboring gene STARR-seq mESC enhancer starr_19756 Neighboring gene PWP1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_19757 Neighboring gene STARR-seq mESC enhancer starr_19760 Neighboring gene STARR-seq mESC enhancer starr_19762 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene synaptotagmin IX

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning. Ehrmann I, et al. Elife, 2019 Jan 24. PMID 30674417, Free PMC Article
    2. Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse. Ehrmann I, et al. Hum Mol Genet, 2008 Sep 15. PMID 18562473
    3. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rbmxl2 retrogene has been conserved across mammals as part of a splicing control mechanism that is fundamentally important to germ cell biology.
      Title: An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.
    2. Haploinsufficiency of hnRNPGT results in abnormal sperm production in the mouse.
      Title: Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif protein, X-linked-like-2
    Names
    testes-specific heterogenous nuclear ribonucleoprotein G-T

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029660.2 → NP_083936.1  RNA-binding motif protein, X-linked-like-2

      See identical proteins and their annotated locations for NP_083936.1

      Status: PROVISIONAL

      Source sequence(s)
      AK005907
      Consensus CDS
      CCDS21689.1
      UniProtKB/TrEMBL
      Q9DAE2
      Related
      ENSMUSP00000095739.2, ENSMUST00000098135.2
      Conserved Domains (3) summary
      COG0724
      Location:9 → 81
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:170 → 214
      RBM1CTR; RBM1CTR (NUC064) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      106808652..106810123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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