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    Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 320398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrig3provided by MGI
    Official Full Name
    leucine-rich repeats and immunoglobulin-like domains 3provided by MGI
    Primary source
    MGI:MGI:2443955
    See related
    Ensembl:ENSMUSG00000020105 AllianceGenome:MGI:2443955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA3016; 9030421L11Rik; 9130004I02Rik; 9430095K15Rik
    Summary
    Acts upstream of or within otolith morphogenesis. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including branchial arch; embryo mesenchyme; nervous system; pancreas tip epithelium; and sensory organ. Orthologous to human LRIG3 (leucine rich repeats and immunoglobulin like domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 28.5), colon adult (RPKM 21.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrig3 in Genome Data Viewer
    Location:
    10 D3; 10 73.66 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (125802088..125851228)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (125966219..126015359)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29862 Neighboring gene STARR-seq mESC enhancer starr_28165 Neighboring gene STARR-seq mESC enhancer starr_28166 Neighboring gene STARR-seq mESC enhancer starr_28167 Neighboring gene predicted gene, 29944 Neighboring gene STARR-seq mESC enhancer starr_28172 Neighboring gene STARR-seq mESC enhancer starr_28173 Neighboring gene STARR-seq mESC enhancer starr_28175 Neighboring gene predicted gene, 30041 Neighboring gene predicted gene 4510

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice. Hellström M, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Jun 1. PMID 27009049
    2. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. Guo D, et al. Genomics, 2004 Jul. PMID 15203213
    3. Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. Abraira VE, et al. PLoS One, 2010 Feb 1. PMID 20126551, Free PMC Article
    4. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Abraira VE, et al. Development, 2008 Dec. PMID 19004851, Free PMC Article
    5. Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation. De Vincenti AP, et al. Development, 2021 Aug 15. PMID 34338291

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
      Title: Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
    2. These findings in mice complement the human epidemiological results and suggest that Lrig3 may influence heart function and plasma lipid levels in mice and humans.
      Title: Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice.
    3. Lrig1 and Lrig3 overlap prominently in the developing vestibular apparatus and simultaneous removal of both genes disrupts inner ear morphogenesis.
      Title: In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
    4. Results suggest that although both Lrig1 and Lrig3 can interact with ErbB receptors in vitro, modulation of Neuregulin signaling is unlikely to contribute to Lrig3-dependent processes of inner ear morphogenesis.
      Title: Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.
    5. mutually antagonistic interactions between Lrig3 and Ntn1 create complementary expression domains that define the future shape of the lateral canal. Removal of one copy of Ntn1 from Lrig3 mutants rescues the circling behavior and the canal malformation.
      Title: Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in otolith morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within otolith morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeats and immunoglobulin-like domains protein 3
    Names
    LIG-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177152.5 → NP_796126.4  leucine-rich repeats and immunoglobulin-like domains protein 3 precursor

      See identical proteins and their annotated locations for NP_796126.4

      Status: VALIDATED

      Source sequence(s)
      AC153489, AK035166, BC065142
      Consensus CDS
      CCDS24219.1
      UniProtKB/Swiss-Prot
      Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4
      Related
      ENSMUSP00000074360.7, ENSMUST00000074807.8
      Conserved Domains (9) summary
      cd05763
      Location:620 → 694
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00408
      Location:711 → 774
      IGc2; Immunoglobulin C-2 Type
      smart00082
      Location:446 → 494
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:81 → 324
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:603 → 693
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:76 → 99
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:147 → 168
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:312 → 371
      LRR_8; Leucine rich repeat
      cl11960
      Location:500 → 587
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      125802088..125851228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1C6.1 GenPept UniProtKB/Swiss-Prot:Q6P1C6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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