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    Tnrc18 trinucleotide repeat containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 231861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnrc18provided by MGI
    Official Full Name
    trinucleotide repeat containing 18provided by MGI
    Primary source
    MGI:MGI:3648294
    See related
    Ensembl:ENSMUSG00000039477 AllianceGenome:MGI:3648294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp469; EG381742
    Summary
    Predicted to enable chromatin binding activity. Predicted to be located in cytosol; mitochondrion; and nucleus. Orthologous to human TNRC18 (trinucleotide repeat containing 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.2), colon adult (RPKM 14.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnrc18 in Genome Data Viewer
    Location:
    5 G2; 5 81.73 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142710357..142812386, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142724602..142823668, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10363 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene STARR-seq mESC enhancer starr_14752 Neighboring gene predicted gene, 40352 Neighboring gene solute carrier family 29 (nucleoside transporters), member 4 Neighboring gene STARR-seq mESC enhancer starr_14754 Neighboring gene STARR-seq mESC enhancer starr_14759 Neighboring gene STARR-seq mESC enhancer starr_14762 Neighboring gene predicted gene, 31365 Neighboring gene predicted gene 15770 Neighboring gene predicted gene, 52793

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Zhao S, et al. Nature, 2023 Nov. PMID 37938770, Free PMC Article
    2. Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia. Chen LL, et al. Mol Cell Endocrinol, 2024 Jan 1. PMID 37774938
    3. Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21). Seedorf H, et al. J Dent Res, 2004 Aug. PMID 15271968
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
      Title: Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59613

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trinucleotide repeat-containing gene 18 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122730.3 → NP_001116202.2  trinucleotide repeat-containing gene 18 protein isoform A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AC144818, AC240265, AK141849, AW491486, BC049818, BC094365, BY713750, CB244319, CB249572
      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Related
      ENSMUSP00000117651.3, ENSMUST00000152247.8
      Conserved Domains (4) summary
      PHA03247
      Location:996 → 1305
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2169 → 2383
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2703 → 2847
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl02573
      Location:2108 → 2174
      Tudor_SF; Tudor domain superfamily

    2. NM_178242.3 → NP_839973.1  trinucleotide repeat-containing gene 18 protein isoform B

      See identical proteins and their annotated locations for NP_839973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) contains an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant A. The resulting isoform (B) contains an alternate internal segment and has a shorter and distinct C-terminus compared to isoform A.
      Source sequence(s)
      AC144818, BC049818, BY713750, CB520310
      Consensus CDS
      CCDS19830.1
      UniProtKB/TrEMBL
      D3YV17
      Related
      ENSMUSP00000114769.3, ENSMUST00000151477.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      142710357..142812386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254452.2 → XP_030110312.1  trinucleotide repeat-containing gene 18 protein isoform X4

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:997 → 1306
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2213 → 2427
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2747 → 2891
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl02573
      Location:2152 → 2218
      Tudor_SF; Tudor domain superfamily

    2. XM_011240976.4 → XP_011239278.1  trinucleotide repeat-containing gene 18 protein isoform X1

      See identical proteins and their annotated locations for XP_011239278.1

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:1049 → 1358
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2265 → 2479
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2799 → 2943
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:2212 → 2264
      Tudor_3; DNA repair protein Crb2 Tudor domain

    3. XM_036165101.1 → XP_036020994.1  trinucleotide repeat-containing gene 18 protein isoform X4

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:997 → 1306
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2213 → 2427
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2747 → 2891
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl02573
      Location:2152 → 2218
      Tudor_SF; Tudor domain superfamily

    4. XM_011240977.4 → XP_011239279.1  trinucleotide repeat-containing gene 18 protein isoform X1

      See identical proteins and their annotated locations for XP_011239279.1

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:1049 → 1358
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2265 → 2479
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2799 → 2943
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:2212 → 2264
      Tudor_3; DNA repair protein Crb2 Tudor domain

    5. XM_030254454.2 → XP_030110314.1  trinucleotide repeat-containing gene 18 protein isoform X5

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:996 → 1305
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2212 → 2426
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2746 → 2890
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:2159 → 2211
      Tudor_3; DNA repair protein Crb2 Tudor domain

    6. XM_006504690.5 → XP_006504753.1  trinucleotide repeat-containing gene 18 protein isoform X4

      See identical proteins and their annotated locations for XP_006504753.1

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:997 → 1306
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2213 → 2427
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2747 → 2891
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl02573
      Location:2152 → 2218
      Tudor_SF; Tudor domain superfamily

    7. XM_006504688.4 → XP_006504751.1  trinucleotide repeat-containing gene 18 protein isoform X2

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:1048 → 1357
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2264 → 2478
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2798 → 2942
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:2211 → 2263
      Tudor_3; DNA repair protein Crb2 Tudor domain

    8. XM_006504689.4 → XP_006504752.1  trinucleotide repeat-containing gene 18 protein isoform X3

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:1049 → 1358
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2222 → 2436
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2756 → 2900
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:2169 → 2221
      Tudor_3; DNA repair protein Crb2 Tudor domain

    9. XM_006504687.4 → XP_006504750.1  trinucleotide repeat-containing gene 18 protein isoform X1

      See identical proteins and their annotated locations for XP_006504750.1

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:1049 → 1358
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2265 → 2479
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2799 → 2943
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:2212 → 2264
      Tudor_3; DNA repair protein Crb2 Tudor domain

    10. XM_030254453.2 → XP_030110313.1  trinucleotide repeat-containing gene 18 protein isoform X4

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:997 → 1306
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2213 → 2427
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2747 → 2891
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl02573
      Location:2152 → 2218
      Tudor_SF; Tudor domain superfamily

    11. XM_030254451.2 → XP_030110311.1  trinucleotide repeat-containing gene 18 protein isoform X4

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:997 → 1306
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2213 → 2427
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2747 → 2891
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl02573
      Location:2152 → 2218
      Tudor_SF; Tudor domain superfamily

    12. XM_006504691.5 → XP_006504754.1  trinucleotide repeat-containing gene 18 protein isoform X6

      UniProtKB/Swiss-Prot
      Q1LZJ7, Q69Z86, Q80WC3
      Conserved Domains (4) summary
      PHA03247
      Location:975 → 1284
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:2191 → 2405
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2725 → 2869
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:2138 → 2190
      Tudor_3; DNA repair protein Crb2 Tudor domain

    13. XM_030254457.2 → XP_030110317.1  trinucleotide repeat-containing gene 18 protein isoform X7

      UniProtKB/TrEMBL
      F6Z7L1
      Conserved Domains (4) summary
      PHA03247
      Location:545 → 854
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:1761 → 1975
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04714
      Location:2295 → 2439
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
      cl07283
      Location:1708 → 1760
      Tudor_3; DNA repair protein Crb2 Tudor domain

    14. XM_036165102.1 → XP_036020995.1  trinucleotide repeat-containing gene 18 protein isoform X8

      Conserved Domains (1) summary
      NF033930
      Location:1035 → 1111
      pneumo_PspA; pneumococcal surface protein A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WC3.2 GenPept UniProtKB/Swiss-Prot:Q80WC3

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