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    Gbp6 guanylate binding protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 100702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gbp6provided by MGI
    Official Full Name
    guanylate binding protein 6provided by MGI
    Primary source
    MGI:MGI:2140937
    See related
    Ensembl:ENSMUSG00000104713 AllianceGenome:MGI:2140937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GBP-6; Mpa2l
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in cellular response to interferon-beta. Acts upstream of or within adhesion of symbiont to host; cellular response to lipopolysaccharide; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; nasal cavity epithelium; submandibular gland primordium; vertebral axis musculature; and vibrissa. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 7.3), liver E18 (RPKM 5.1) and 24 other tissues See more
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    Genomic context

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    See Gbp6 in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105418568..105443733, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105270702..105295871, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9640 Neighboring gene predicted gene, 31785 Neighboring gene guanylate-binding protein 10 Neighboring gene STARR-seq mESC enhancer starr_13849 Neighboring gene guanylate binding protein 11 Neighboring gene predicted gene, 26519

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
    2. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
    3. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Bürckstümmer T, et al. Nat Immunol, 2009 Mar. PMID 19158679
    4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adhesion of symbiont to host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate-binding protein 6
    Names
    GTP-binding protein 6
    guanine nucleotide-binding protein 6
    macrophage activation 2 like
    macrophage activation 2 like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194336.2 → NP_919317.2  guanylate-binding protein 6

      See identical proteins and their annotated locations for NP_919317.2

      Status: VALIDATED

      Source sequence(s)
      AC123697, AK152226, BB657433, BQ562803, BX525828, BY159737
      Consensus CDS
      CCDS19492.1
      UniProtKB/Swiss-Prot
      A0A0G2JDV3, Q6PEN2, Q6ZQL8
      UniProtKB/TrEMBL
      A0A8Q0QEH4, L7N1X8
      Related
      ENSMUSP00000142518.2, ENSMUST00000196520.2
      Conserved Domains (2) summary
      pfam02263
      Location:16 → 279
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:281 → 575
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105418568..105443733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534688.4 → XP_006534751.1  guanylate-binding protein 6 isoform X4

      UniProtKB/Swiss-Prot
      A0A0G2JDV3, Q6PEN2, Q6ZQL8
      UniProtKB/TrEMBL
      L7N1X8
      Conserved Domains (2) summary
      pfam02841
      Location:231 → 525
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:10 → 229
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006534687.4 → XP_006534750.1  guanylate-binding protein 6 isoform X2

      See identical proteins and their annotated locations for XP_006534750.1

      UniProtKB/Swiss-Prot
      A0A0G2JDV3, Q6PEN2, Q6ZQL8
      UniProtKB/TrEMBL
      A0A8Q0QEH4, L7N1X8
      Conserved Domains (2) summary
      pfam02263
      Location:16 → 279
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:281 → 575
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. XM_006534690.5 → XP_006534753.2  guanylate-binding protein 6 isoform X3

      UniProtKB/TrEMBL
      Q05DL4
      Conserved Domains (2) summary
      pfam02841
      Location:258 → 552
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:81 → 256
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_006534689.5 → XP_006534752.1  guanylate-binding protein 6 isoform X5

      See identical proteins and their annotated locations for XP_006534752.1

      UniProtKB/TrEMBL
      Q05DL4
      Conserved Domains (2) summary
      pfam02841
      Location:204 → 498
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:1 → 202
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_011249385.4 → XP_011247687.1  guanylate-binding protein 6 isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2JDV3, Q6PEN2, Q6ZQL8
      UniProtKB/TrEMBL
      L7N1X8
      Conserved Domains (2) summary
      pfam02263
      Location:105 → 368
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:370 → 664
      GBP_C; Guanylate-binding protein, C-terminal domain

    6. XM_006534691.3 → XP_006534754.1  guanylate-binding protein 6 isoform X5

      See identical proteins and their annotated locations for XP_006534754.1

      UniProtKB/TrEMBL
      Q05DL4
      Conserved Domains (2) summary
      pfam02841
      Location:204 → 498
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:1 → 202
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0G2JDV3.2 GenPept UniProtKB/Swiss-Prot:A0A0G2JDV3

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