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    Adgb androglobin [ Mus musculus (house mouse) ]

    Gene ID: 215772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgbprovided by MGI
    Official Full Name
    androglobinprovided by MGI
    Primary source
    MGI:MGI:3605549
    See related
    Ensembl:ENSMUSG00000050994 AllianceGenome:MGI:3605549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130014G24Rik
    Summary
    Predicted to enable several functions, including calcium-dependent cysteine-type endopeptidase activity; heme binding activity; and oxygen binding activity. Involved in spermatid development. Located in sperm annulus and sperm midpiece. Is expressed in lung. Orthologous to human ADGB (androglobin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 5.3), liver E18 (RPKM 0.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgb in Genome Data Viewer
    Location:
    10 A1; 10 3.44 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (10211447..10350837, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (10335703..10475093, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930598N05 gene Neighboring gene predicted gene, 31904 Neighboring gene STARR-seq mESC enhancer starr_25741 Neighboring gene STARR-positive B cell enhancer mm9_chr10:10055172-10055473 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25742 Neighboring gene STARR-seq mESC enhancer starr_25744 Neighboring gene STARR-seq mESC enhancer starr_25746 Neighboring gene RAB32, member RAS oncogene family Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. Hoogewijs D, et al. Mol Biol Evol, 2012 Apr. PMID 22115833, Free PMC Article
    2. ADGB variants cause asthenozoospermia and male infertility. Qu R, et al. Hum Genet, 2023 Jun. PMID 36995441
    3. Androglobin, a chimeric mammalian globin, is required for male fertility. Keppner A, et al. Elife, 2022 Jun 14. PMID 35700329, Free PMC Article
    4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADGB variants cause asthenozoospermia and male infertility.
      Title: ADGB variants cause asthenozoospermia and male infertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in sperm annulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm annulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    androglobin
    Names
    calpain-7-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127353.4 → NP_001120825.3  androglobin

      Status: VALIDATED

      Source sequence(s)
      AC153567, AC159380
      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      10211447..10350837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243163.3 → XP_011241465.1  androglobin isoform X5

      UniProtKB/TrEMBL
      A0A140LI36
      Conserved Domains (2) summary
      PTZ00121
      Location:1284 → 1651
      PTZ00121; MAEBL; Provisional
      cl00051
      Location:200 → 307
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    2. XM_017313876.2 → XP_017169365.1  androglobin isoform X4

      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7
      Conserved Domains (2) summary
      PTZ00121
      Location:1310 → 1677
      PTZ00121; MAEBL; Provisional
      cl00051
      Location:200 → 307
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    3. XM_030244999.1 → XP_030100859.1  androglobin isoform X7

      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7
      Conserved Domains (2) summary
      pfam09731
      Location:1329 → 1639
      Mitofilin; Mitochondrial inner membrane protein
      cl00051
      Location:200 → 307
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    4. XM_011243160.3 → XP_011241462.1  androglobin isoform X2

      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7
      Conserved Domains (2) summary
      PTZ00121
      Location:1328 → 1695
      PTZ00121; MAEBL; Provisional
      cl00051
      Location:200 → 307
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    5. XM_017313877.2 → XP_017169366.1  androglobin isoform X6

      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7
      Conserved Domains (2) summary
      PTZ00121
      Location:1332 → 1640
      PTZ00121; MAEBL; Provisional
      cl00051
      Location:200 → 307
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    6. XM_017313875.2 → XP_017169364.1  androglobin isoform X1

      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7
      Conserved Domains (2) summary
      PTZ00121
      Location:1329 → 1696
      PTZ00121; MAEBL; Provisional
      cl00051
      Location:200 → 307
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    7. XM_017313879.3 → XP_017169368.1  androglobin isoform X10

      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7
      Related
      ENSMUSP00000134378.2, ENSMUST00000172530.8
      Conserved Domains (2) summary
      PTZ00121
      Location:1296 → 1663
      PTZ00121; MAEBL; Provisional
      cl00051
      Location:186 → 293
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    8. XM_006512658.5 → XP_006512721.1  androglobin isoform X3

      UniProtKB/Swiss-Prot
      G3UZ78, Q8C5C7
      Conserved Domains (2) summary
      PTZ00121
      Location:1315 → 1682
      PTZ00121; MAEBL; Provisional
      cl00051
      Location:186 → 293
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    9. XM_006512663.4 → XP_006512726.1  androglobin isoform X8

      Conserved Domains (1) summary
      PTZ00121
      Location:896 → 1263
      PTZ00121; MAEBL; Provisional

    10. XM_017313878.2 → XP_017169367.1  androglobin isoform X9

      Conserved Domains (1) summary
      cl00051
      Location:200 → 307
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172547.3: Suppressed sequence

      Description
      NM_172547.3: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3UZ78.1 GenPept UniProtKB/Swiss-Prot:G3UZ78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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