U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Igf1r insulin-like growth factor I receptor [ Mus musculus (house mouse) ]

    Gene ID: 16001, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Igf1rprovided by MGI
    Official Full Name
    insulin-like growth factor I receptorprovided by MGI
    Primary source
    MGI:MGI:96433
    See related
    Ensembl:ENSMUSG00000005533 AllianceGenome:MGI:96433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hyft; CD221; IGF-1R; D930020L01; A330103N21Rik
    Summary
    Enables insulin-like growth factor binding activity and insulin-like growth factor receptor activity. Involved in several processes, including adrenal gland development; insulin-like growth factor receptor signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including exocrine pancreas development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.6), kidney adult (RPKM 10.1) and 27 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Igf1r in Genome Data Viewer
    Location:
    7 C; 7 37.27 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (67601486..67883416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (67952257..68233668)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833412C05 gene Neighboring gene predicted gene, 34350 Neighboring gene STARR-seq mESC enhancer starr_19103 Neighboring gene predicted gene, 39027 Neighboring gene STARR-seq mESC enhancer starr_19104 Neighboring gene STARR-positive B cell enhancer ABC_E9692 Neighboring gene predicted gene, 51487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75350823-75351006 Neighboring gene pyroglutamyl-peptidase I-like Neighboring gene STARR-positive B cell enhancer ABC_E8177 Neighboring gene STARR-seq mESC enhancer starr_19114 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75434034-75434217 Neighboring gene family with sequence similarity 169, member B Neighboring gene aging liver Treg-expressed non-protein coding RNA Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:75468056-75468239 Neighboring gene predicted gene 16158

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Effects of insulin-like growth factor-1 (IGF-1) receptor signaling on rates of apoptosis in retina of dopamine beta hydroxylase (Dbh-/-) knockout mice. Panjala SR, et al. Auton Neurosci, 2010 Jan 15. PMID 19748322, Free PMC Article
    2. Reversibility and recurrence of IGF-IR-induced mammary tumors. Jones RA, et al. Oncogene, 2009 May 28. PMID 19377512
    3. Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation. Landau D, et al. Endocrine, 2009 Aug. PMID 19387875
    4. [IGF-1 receptors in the brain control longevity in mice]. Holzenberger M. Med Sci (Paris), 2009 Apr. PMID 19409189
    5. Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death. Tseng YT, et al. Nutr Neurosci, 2021 Jan. PMID 30900959

    See all (630) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    Submit: New GeneRIF Correction See all GeneRIFs (298)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Items 1 - 25 of 46
    Function Evidence Code Pubs
    enables ATP binding  
    enables G-protein alpha-subunit binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding  
    enables insulin binding  
    enables insulin receptor activity  
    enables insulin receptor activity  
    enables insulin receptor binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables insulin-like growth factor I binding  
    enables insulin-like growth factor binding PubMed 
    enables insulin-like growth factor binding  
    enables insulin-like growth factor binding  
    enables insulin-like growth factor receptor activity PubMed 
    enables insulin-like growth factor receptor activity PubMed 
    enables insulin-like growth factor receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables phosphatidylinositol 3-kinase binding  
    enables phosphatidylinositol 3-kinase binding  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein transporter activity  
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein-containing complex binding  
    enables stem cell factor receptor activity  
    enables structural molecule activity  
    enables structural molecule activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 46
    Items 1 - 25 of 86
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    acts_upstream_of MAPK cascade PubMed 
    involved_in adrenal gland development PubMed 
    involved_in amyloid-beta clearance  
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    involved_in axonogenesis  
    acts_upstream_of_or_within brain development PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to glucose stimulus  
    acts_upstream_of_or_within cellular response to glucose stimulus PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus PubMed 
    involved_in cellular response to insulin-like growth factor stimulus  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in cerebellum development  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in dendritic spine maintenance  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    acts_upstream_of_or_within epidermis development PubMed 
    involved_in establishment of cell polarity  
    involved_in estrous cycle  
    acts_upstream_of_or_within exocrine pancreas development PubMed 
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in immune response  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    acts_upstream_of_or_within male sex determination PubMed 
    acts_upstream_of_or_within mammary gland development PubMed 
    acts_upstream_of mitotic nuclear division PubMed 
    involved_in multicellular organism development  
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cholangiocyte apoptotic process  
    involved_in negative regulation of hepatocyte apoptotic process  
    involved_in negative regulation of muscle cell apoptotic process  
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in neuron projection development  
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation PubMed 
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of DNA metabolic process  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of axon regeneration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of developmental growth PubMed 
    involved_in positive regulation of meiotic cell cycle PubMed 
    acts_upstream_of_or_within positive regulation of mitotic nuclear division PubMed 
    involved_in positive regulation of osteoblast proliferation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein-containing complex disassembly  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of steroid hormone biosynthetic process  
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    acts_upstream_of_or_within prostate gland epithelium morphogenesis PubMed 
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in regulation of JNK cascade  
    involved_in regulation of JNK cascade  
    involved_in response to L-glutamate  
    involved_in response to ethanol  
    involved_in transcytosis  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 86
    Component Evidence Code Pubs
    located_in T-tubule PubMed 
    located_in T-tubule  
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex  
    is_active_in axon  
    located_in axon  
    located_in caveola  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    part_of insulin receptor complex  
    located_in intracellular membrane-bounded organelle  
    located_in membrane PubMed 
    located_in membrane  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynapse  
    part_of protein kinase complex  
    part_of receptor complex PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    insulin-like growth factor 1 receptor
    Names
    IGF-I receptor
    line 186
    NP_034643.2
    XP_006540704.1
    XP_006540705.1
    XP_006540706.1
    XP_006540707.1
    XP_006540708.1
    XP_017177475.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010513.3 → NP_034643.2  insulin-like growth factor 1 receptor precursor

      See identical proteins and their annotated locations for NP_034643.2

      Status: VALIDATED

      Source sequence(s)
      AC101879, AC158584
      Consensus CDS
      CCDS21355.1
      UniProtKB/TrEMBL
      E9QNX9
      Related
      ENSMUSP00000005671.9, ENSMUST00000005671.10
      Conserved Domains (7) summary
      cd05032
      Location:993 → 1270
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:836 → 925
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:230 → 277
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:175 → 330
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353 → 467
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:1000 → 1265
      Pkinase_Tyr; Protein tyrosine kinase
      cl22855
      Location:207 → 336
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      67601486..67883416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540642.5 → XP_006540705.1  insulin-like growth factor 1 receptor isoform X2

      Conserved Domains (4) summary
      cd05032
      Location:993 → 1301
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:836 → 925
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:175 → 332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353 → 466
      Recep_L_domain; Receptor L domain

    2. XM_006540641.5 → XP_006540704.1  insulin-like growth factor 1 receptor isoform X1

      Conserved Domains (4) summary
      cd05032
      Location:994 → 1302
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:837 → 926
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:175 → 332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353 → 466
      Recep_L_domain; Receptor L domain

    3. XM_006540643.5 → XP_006540706.1  insulin-like growth factor 1 receptor isoform X3

      Conserved Domains (4) summary
      cd05032
      Location:994 → 1271
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:837 → 926
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:175 → 332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353 → 466
      Recep_L_domain; Receptor L domain

    4. XM_006540644.4 → XP_006540707.1  insulin-like growth factor 1 receptor isoform X4

      Conserved Domains (4) summary
      cd05032
      Location:798 → 1106
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:641 → 730
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:19 → 136
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:157 → 270
      Recep_L_domain; Receptor L domain

    5. XM_006540645.4 → XP_006540708.1  insulin-like growth factor 1 receptor isoform X5

      See identical proteins and their annotated locations for XP_006540708.1

      UniProtKB/TrEMBL
      Q3U1L4
      Conserved Domains (4) summary
      cd05032
      Location:797 → 1074
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:640 → 729
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:19 → 136
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:157 → 270
      Recep_L_domain; Receptor L domain

    6. XM_017321986.3 → XP_017177475.1  insulin-like growth factor 1 receptor isoform X6

      UniProtKB/TrEMBL
      Q3UVJ3
      Conserved Domains (4) summary
      cd05032
      Location:691 → 999
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:534 → 623
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:1 → 29
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:50 → 163
      Recep_L_domain; Receptor L domain
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60751.3 GenPept UniProtKB/Swiss-Prot:Q60751

    External link. Please review our privacy policy.