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    Taf6l TATA-box binding protein associated factor 6 like [ Mus musculus (house mouse) ]

    Gene ID: 225895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf6lprovided by MGI
    Official Full Name
    TATA-box binding protein associated factor 6 likeprovided by MGI
    Primary source
    MGI:MGI:2444957
    See related
    Ensembl:ENSMUSG00000003680 AllianceGenome:MGI:2444957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paf65a; 2810417N14Rik; C530024J06Rik
    Summary
    Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in tail. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 17.2), ovary adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf6l in Genome Data Viewer
    Location:
    19 A; 19 5.56 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8751718..8763781, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8774354..8786417, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45493 Neighboring gene nuclear RNA export factor 1 Neighboring gene transmembrane protein 223 Neighboring gene transmembrane protein 179B Neighboring gene interferon induced transmembrane protein 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2519 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide G Neighboring gene STARR-positive B cell enhancer ABC_E173 Neighboring gene zinc finger and BTB domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs. Chen J, et al. Endocrinology, 2009 Oct. PMID 19574399
    2. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Seruggia D, et al. Mol Cell, 2019 Jun 20. PMID 31005419, Free PMC Article
    3. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Floyd JA, et al. Nat Genet, 2003 Nov. PMID 14517553, Free PMC Article
    4. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. Schiltz RL, et al. J Biol Chem, 1999 Jan 15. PMID 9880483
    5. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network.
      Title: TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.
    2. Gonadotropin-releasing hormone-mediated phosphorylation of ERalpha in LbetaT2 pituitary cells results in its rapid association with p300-CBP-associated factor and the transcriptional activation of fosB.
      Title: Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC41377

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of somatic stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
    Names
    PAF65-alpha
    PCAF-associated factor 65-alpha
    TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177798.1 → NP_001171269.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC025794, AK077149, BC028647
      Consensus CDS
      CCDS57134.1
      UniProtKB/TrEMBL
      A0A087WQC4, H3BJR2
      Related
      ENSMUSP00000135090.2, ENSMUST00000176496.8
      Conserved Domains (2) summary
      cd08050
      Location:20 → 304
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl21461
      Location:298 → 356
      Globin_like; Globin-like proteins

    2. NM_146092.2 → NP_666204.2  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AC025794, BC028647, BY295292
      Consensus CDS
      CCDS29546.2
      UniProtKB/TrEMBL
      H3BK01, K3W4L1
      Related
      ENSMUSP00000135193.2, ENSMUST00000176610.9
      Conserved Domains (2) summary
      cd08050
      Location:20 → 329
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl21461
      Location:323 → 381
      Globin_like; Globin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8751718..8763781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2K4.1 GenPept UniProtKB/Swiss-Prot:Q8R2K4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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