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    Hpf1 histone PARylation factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hpf1provided by MGI
    Official Full Name
    histone PARylation factor 1provided by MGI
    Primary source
    MGI:MGI:1919862
    See related
    Ensembl:ENSMUSG00000038005 AllianceGenome:MGI:1919862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C4orf27; 2700029M09Rik; C230006B22Rik
    Summary
    Predicted to enable several functions, including histone binding activity; poly-ADP-D-ribose binding activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Predicted to be involved in DNA repair-dependent chromatin remodeling and double-strand break repair. Predicted to be located in chromatin and site of DNA damage. Predicted to be active in nucleus. Orthologous to human HPF1 (histone PARylation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 10.8), CNS E11.5 (RPKM 10.1) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hpf1 in Genome Data Viewer
    Location:
    8 B3.1; 8 30.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61342533..61360615)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (60890392..60907580)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STAM binding protein, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_21566 Neighboring gene predicted gene, 23329 Neighboring gene STARR-seq mESC enhancer starr_21571 Neighboring gene STARR-seq mESC enhancer starr_21573 Neighboring gene STARR-positive B cell enhancer mm9_chr8:63369016-63369317 Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene predicted gene, 18394 Neighboring gene STARR-seq mESC enhancer starr_21578 Neighboring gene STARR-positive B cell enhancer ABC_E10500 Neighboring gene STARR-positive B cell enhancer ABC_E6639 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E11383

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. Sun FH, et al. Nat Commun, 2021 Feb 15. PMID 33589610, Free PMC Article
    2. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
      Title: HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly-ADP-D-ribose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein ADP-ribosyltransferase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein ADP-ribosyltransferase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    histone PARylation factor 1
    Names
    UPF0609 protein C4orf27 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379027.1 → NP_001365956.1  histone PARylation factor 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (3).
      Source sequence(s)
      AC114920
      Conserved Domains (1) summary
      pfam10228
      Location:78 → 338
      DUF2228; Uncharacterized conserved protein (DUF2228)

    2. NM_001379028.1 → NP_001365957.1  histone PARylation factor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114920
      Conserved Domains (1) summary
      pfam10228
      Location:16 → 128
      DUF2228; Uncharacterized conserved protein (DUF2228)

    3. NM_028299.3 → NP_082575.1  histone PARylation factor 1 isoform 1

      See identical proteins and their annotated locations for NP_082575.1

      Status: VALIDATED

      Source sequence(s)
      AC114920
      Consensus CDS
      CCDS52553.1
      UniProtKB/Swiss-Prot
      Q8CFE2
      Related
      ENSMUSP00000047235.9, ENSMUST00000037190.15
      Conserved Domains (1) summary
      pfam10228
      Location:78 → 328
      DUF2228; Uncharacterized conserved protein (DUF2228)

    RNA

    1. NR_151662.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920
      Related
      ENSMUST00000146863.2

    2. NR_166421.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920
      Related
      ENSMUST00000149267.8

    3. NR_166422.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920

    4. NR_166424.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920

    5. NR_166425.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920

    6. NR_166426.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920

    7. NR_166427.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920

    8. NR_166428.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920

    9. NR_166429.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114920

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      61342533..61360615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154312.1 → XP_036010205.1  histone PARylation factor 1 isoform X3

      Conserved Domains (1) summary
      pfam10228
      Location:1 → 169
      DUF2228; Uncharacterized conserved protein (DUF2228)

    2. XM_036154311.1 → XP_036010204.1  histone PARylation factor 1 isoform X3

      Conserved Domains (1) summary
      pfam10228
      Location:1 → 169
      DUF2228; Uncharacterized conserved protein (DUF2228)

    3. XM_006509512.5 → XP_006509575.1  histone PARylation factor 1 isoform X2

      Conserved Domains (1) summary
      pfam10228
      Location:79 → 320
      DUF2228; Uncharacterized conserved protein (DUF2228)

    4. XM_006509510.5 → XP_006509573.1  histone PARylation factor 1 isoform X1

      Conserved Domains (1) summary
      pfam10228
      Location:79 → 330
      DUF2228; Uncharacterized conserved protein (DUF2228)

    RNA

    1. XR_378914.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFE2.1 GenPept UniProtKB/Swiss-Prot:Q8CFE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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