Cib4 calcium and integrin binding family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cib4provided by MGI
Official Full Name: calcium and integrin binding family member 4provided by MGI
Primary source: MGI:MGI:1920509
See related: Ensembl:ENSMUSG00000053194 AllianceGenome:MGI:1920509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700041E20Rik
Summary: Predicted to enable calcium ion binding activity and magnesium ion binding activity. Orthologous to human CIB4 (calcium and integrin binding family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 41.5) See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 16.59 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (30642927..30703191, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (30485583..30545845, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CIB4 is essential for the haploid phase of spermatogenesis in micedagger.
Title: CIB4 is essential for the haploid phase of spermatogenesis in mice†.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: calcium and integrin-binding family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417805.1 → NP_001404734.1 calcium and integrin-binding family member 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC157761
NM_001417806.1 → NP_001404735.1 calcium and integrin-binding family member 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC157761
NM_028483.2 → NP_082759.1 calcium and integrin-binding family member 4 isoform 1

See identical proteins and their annotated locations for NP_082759.1

Status: VALIDATED

Source sequence(s)

AC157761

Consensus CDS

CCDS51453.1

UniProtKB/Swiss-Prot

Q9D9N5

Related

ENSMUSP00000066222.3, ENSMUST00000065486.3

Conserved Domains (2) summary

COG5126
Location:21 → 173

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:101 → 169

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...