P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2rx6provided by MGI
Official Full Name: purinergic receptor P2X, ligand-gated ion channel, 6provided by MGI
Primary source: MGI:MGI:1337113
See related: Ensembl:ENSMUSG00000022758 AllianceGenome:MGI:1337113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2x6; P2xm; P2rxl1
Summary: Predicted to enable extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in cytoplasm; dendritic spine; and neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic specialization membrane. Is expressed in central nervous system; heart; parathyroid gland; reproductive system; and respiratory system. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 7.9), ovary adult (RPKM 5.8) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 10.88 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17379749..17389879)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17561867..17572015)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

purinergic signaling via P2X6 is not significantly involved in the regulation of renal electrolyte handling under normal physiological conditions.
Title: P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis.
once inside the nucleus, P2X6 subunit interacts with the splicing factor 3A1, which ultimately results in a reduction of the mRNA splicing activity
Title: Age-related nuclear translocation of P2X6 subunit modifies splicing activity interacting with splicing factor 3A1.
This study provides the first evidence that P2X8 receptors are expressed on LHRH-containing neurons.
Title: P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus.
Immunoreactivity for P2X3-, P2X5-, and P2X6-purinoceptors was observed in mouse retina.
Title: Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487447

AB010883 (e-PCR)
- UniSTS:160535

D11Wox5 (e-PCR)
- UniSTS:517791

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in parallel fiber to Purkinje cell synapse	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P2X purinoceptor 6

Names: ATP receptor; purinergic receptor P2X-like 1, orphan receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159561.1 → NP_001153033.1 P2X purinoceptor 6 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AK138541, AW490413, BC117713, BY303078

Consensus CDS

CCDS49778.1

UniProtKB/TrEMBL

E9PY29, Q149L9

Related

ENSMUSP00000132727.2, ENSMUST00000171002.10

Conserved Domains (1) summary

TIGR00863
Location:19 → 349

P2X; cation transporter protein
NM_011028.2 → NP_035158.2 P2X purinoceptor 6 isoform 1

See identical proteins and their annotated locations for NP_035158.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK138541, AW490413, BY303078

Consensus CDS

CCDS28007.2

UniProtKB/Swiss-Prot

G3X8W3, O54803, Q3UUD0

UniProtKB/TrEMBL

Q149L9

Related

ENSMUSP00000023441.5, ENSMUST00000023441.11

Conserved Domains (1) summary

TIGR00863
Location:19 → 376

P2X; cation transporter protein