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    Atg10 autophagy related 10 [ Mus musculus (house mouse) ]

    Gene ID: 66795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atg10provided by MGI
    Official Full Name
    autophagy related 10provided by MGI
    Primary source
    MGI:MGI:1914045
    See related
    Ensembl:ENSMUSG00000021619 AllianceGenome:MGI:1914045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APG10; Agp10; Apg10l; Apg10p; Atg10l; mAPG10; 5330424L23Rik; 5430428K15Rik
    Summary
    Enables Atg12 conjugating enzyme activity. Acts upstream of or within positive regulation of protein modification process and protein lipidation. Predicted to be located in cytosol. Orthologous to human ATG10 (autophagy related 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.2), heart adult (RPKM 0.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atg10 in Genome Data Viewer
    Location:
    13 C3; 13 46.46 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (91083467..91372189, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (90935348..91224725, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1-like Neighboring gene STARR-positive B cell enhancer ABC_E3091 Neighboring gene ribosomal protein S23 Neighboring gene STARR-seq mESC enhancer starr_35246 Neighboring gene STARR-seq mESC enhancer starr_35249 Neighboring gene STARR-seq mESC enhancer starr_35250 Neighboring gene 40S ribosomal protein S14 pseudogene Neighboring gene predicted gene, 41014 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene Neighboring gene RIKEN cDNA A830009L08 gene Neighboring gene STARR-seq mESC enhancer starr_35251 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:91510584-91510802

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. Mizushima N, et al. FEBS Lett, 2002 Dec 18. PMID 12482611
    2. The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. Nemoto T, et al. J Biol Chem, 2003 Oct 10. PMID 12890687
    3. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Radoshevich L, et al. Cell, 2010 Aug 20. PMID 20723759, Free PMC Article
    4. Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival. Li H, et al. Cell Rep, 2022 Oct 4. PMID 36198274
    5. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The isolated mouse APG10 gene product interacts with mammalian Apg12p dependent on mammalian Apg7p (E1-like enzyme), and facilitates Apg12p conjugation.
      Title: The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.
    2. APG10 has a role in mediating the conjugation of APG12 with APG5
      Title: Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Atg12 conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Atg12 conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Atg12 conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Atg12 transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables Atg12 transferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ER overload response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein modification process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein lipidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification by small protein conjugation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like-conjugating enzyme ATG10
    Names
    autophagy-related protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404917.1 → NP_001391846.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7
      UniProtKB/TrEMBL
      A0A0R4J029

    2. NM_001404918.1 → NP_001391847.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7
      UniProtKB/TrEMBL
      A0A0R4J029

    3. NM_001404919.1 → NP_001391848.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7
      UniProtKB/TrEMBL
      A0A0R4J029

    4. NM_001404920.1 → NP_001391849.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7
      UniProtKB/TrEMBL
      A0A0R4J029

    5. NM_001404921.1 → NP_001391850.1  ubiquitin-like-conjugating enzyme ATG10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7

    6. NM_001404922.1 → NP_001391851.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7

    7. NM_001404923.1 → NP_001391852.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7

    8. NM_001404925.1 → NP_001391854.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980

    9. NM_001404926.1 → NP_001391855.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980

    10. NM_001404927.1 → NP_001391856.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980

    11. NM_001404928.1 → NP_001391857.1  ubiquitin-like-conjugating enzyme ATG10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC160980

    12. NM_025770.4 → NP_080046.3  ubiquitin-like-conjugating enzyme ATG10 isoform 1

      See identical proteins and their annotated locations for NP_080046.3

      Status: VALIDATED

      Source sequence(s)
      AC108947, AC134461, AC160980
      Consensus CDS
      CCDS26675.1
      UniProtKB/Swiss-Prot
      Q8BPA9, Q8R1P4, Q9D3J7
      UniProtKB/TrEMBL
      A0A0R4J029
      Related
      ENSMUSP00000022119.5, ENSMUST00000022119.6
      Conserved Domains (1) summary
      pfam03987
      Location:95 → 162
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      91083467..91372189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244552.4 → XP_011242854.1  ubiquitin-like-conjugating enzyme ATG10 isoform X3

      Conserved Domains (1) summary
      pfam03987
      Location:54 → 121
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    RNA

    1. XR_873450.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1P4.1 GenPept UniProtKB/Swiss-Prot:Q8R1P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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