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    Itgb1bp1 integrin beta 1 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16413, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itgb1bp1provided by MGI
    Official Full Name
    integrin beta 1 binding protein 1provided by MGI
    Primary source
    MGI:MGI:1306802
    See related
    Ensembl:ENSMUSG00000062352 AllianceGenome:MGI:1306802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Icap1
    Summary
    Enables protein kinase binding activity. Involved in several processes, including integrin activation; positive regulation of stress fiber assembly; and regulation of cell-substrate adhesion. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Is expressed in left lung and right lung. Orthologous to human ITGB1BP1 (integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 30.9), subcutaneous fat pad adult (RPKM 11.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Itgb1bp1 in Genome Data Viewer
    Location:
    12 A1.3; 12 8.3 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (21317247..21336285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (21267246..21286292, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31717 Neighboring gene predicted gene 5977 Neighboring gene STARR-seq mESC enhancer starr_31718 Neighboring gene STARR-seq mESC enhancer starr_31719 Neighboring gene STARR-seq mESC enhancer starr_31721 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene STARR-seq mESC enhancer starr_31722 Neighboring gene predicted gene, 40855 Neighboring gene predicted gene, 25821 Neighboring gene cleavage and polyadenylation specificity factor 3 Neighboring gene a disintegrin and metallopeptidase domain 17 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity  
    enables GDP-dissociation inhibitor activity  
    enables integrin binding  
    enables integrin binding  
    enables kinase binding PubMed 
    enables protein binding PubMed 
    enables protein binding  
    enables protein kinase binding PubMed 
    Items 1 - 25 of 65
    Process Evidence Code Pubs
    involved_in Notch signaling pathway  
    involved_in activation of protein kinase B activity  
    involved_in activation of protein kinase B activity  
    involved_in biomineral tissue development  
    involved_in blood vessel diameter maintenance  
    involved_in blood vessel diameter maintenance  
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    involved_in cell differentiation  
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in cellular response to fibroblast growth factor stimulus  
    involved_in cellular response to fibroblast growth factor stimulus  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in integrin activation PubMed 
    involved_in integrin activation  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in myoblast migration PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of cell adhesion involved in substrate-bound cell migration PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of fibroblast migration PubMed 
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of focal adhesion assembly PubMed 
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of protein binding  
    involved_in negative regulation of protein binding  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein targeting to membrane  
    involved_in negative regulation of protein targeting to membrane  
    involved_in negative regulation of substrate adhesion-dependent cell spreading  
    involved_in negative regulation of substrate adhesion-dependent cell spreading PubMed 
    involved_in negative regulation of substrate adhesion-dependent cell spreading  
    involved_in negative regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of Notch signaling pathway  
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of focal adhesion assembly PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein targeting to membrane PubMed 
    involved_in positive regulation of stress fiber assembly PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein localization to plasma membrane  
    involved_in receptor clustering PubMed 
    involved_in regulation of GTPase activity  
    involved_in regulation of GTPase activity  
    acts_upstream_of_or_within regulation of cell adhesion  
    involved_in regulation of cell adhesion mediated by integrin PubMed 
    involved_in regulation of integrin-mediated signaling pathway PubMed 
    involved_in regulation of integrin-mediated signaling pathway PubMed 
    involved_in tube formation  
    involved_in tube formation  
    Items 1 - 25 of 65
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    is_active_in cell periphery  
    located_in cell periphery  
    located_in cell periphery  
    located_in centriolar satellite  
    located_in centriolar satellite  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoskeleton  
    located_in cytoskeleton PubMed 
    located_in cytosol  
    located_in cytosol  
    NOT located_in focal adhesion  
    is_active_in lamellipodium  
    located_in lamellipodium PubMed 
    located_in lamellipodium  
    located_in lamellipodium  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane PubMed 
    is_active_in ruffle  
    located_in ruffle PubMed 
    located_in ruffle  
    located_in ruffle  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    integrin beta-1-binding protein 1
    Names
    bodenin
    integrin cytoplasmic domain-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355609.1NP_001342538.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK007635, AK075577, BE947737, BY085309, CX238278
      Consensus CDS
      CCDS25833.1
      UniProtKB/Swiss-Prot
      O35671, Q542A8
      UniProtKB/TrEMBL
      Q3UGH2
      Related
      ENSMUSP00000134627.2, ENSMUST00000173729.8
      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    2. NM_008403.5NP_032429.1  integrin beta-1-binding protein 1

      See identical proteins and their annotated locations for NP_032429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC156032, AK075577, BE947737, BY085309
      Consensus CDS
      CCDS25833.1
      UniProtKB/Swiss-Prot
      O35671, Q542A8
      UniProtKB/TrEMBL
      Q3UGH2
      Related
      ENSMUSP00000075609.5, ENSMUST00000076260.12
      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      21317247..21336285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514989.4XP_006515052.1  integrin beta-1-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006515052.1

      UniProtKB/TrEMBL
      Q3UGH2
      Conserved Domains (1) summary
      cl17171
      Location:1177
      PH-like; Pleckstrin homology-like domain
    2. XM_006514990.5XP_006515053.1  integrin beta-1-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006515053.1

      UniProtKB/TrEMBL
      Q3UGH2
      Conserved Domains (1) summary
      cl17171
      Location:1177
      PH-like; Pleckstrin homology-like domain
    3. XM_011243816.4XP_011242118.1  integrin beta-1-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3UGH2
      Related
      ENSMUSP00000134508.2, ENSMUST00000172834.2
      Conserved Domains (1) summary
      cl17171
      Location:1177
      PH-like; Pleckstrin homology-like domain
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