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    Oxct1 3-oxoacid CoA transferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67041, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oxct1provided by MGI
    Official Full Name
    3-oxoacid CoA transferase 1provided by MGI
    Primary source
    MGI:MGI:1914291
    See related
    Ensembl:ENSMUSG00000022186 AllianceGenome:MGI:1914291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oxct; SCOT; Oxct2a; Scot-s; 2610008O03Rik
    Summary
    Enables succinyl-CoA:3-oxo-acid CoA-transferase activity. Acts upstream of or within ketone body catabolic process and ketone catabolic process. Located in mitochondrion. Is expressed in foregut and heart. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 155.7), heart adult (RPKM 139.3) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Oxct1 in Genome Data Viewer
    Location:
    15 A1; 15 1.86 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (4055910..4184826)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (4026428..4155344)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37819 Neighboring gene RAB7A interacting MON1-CCZ1 complex subunit 1 Neighboring gene predicted gene 2093 Neighboring gene 3-oxoacid CoA transferase 1 antisense RNA Neighboring gene STARR-seq mESC enhancer starr_37822 Neighboring gene STARR-seq mESC enhancer starr_37823 Neighboring gene STARR-seq mESC enhancer starr_37824 Neighboring gene STARR-seq mESC enhancer starr_37825 Neighboring gene STARR-seq mESC enhancer starr_37827 Neighboring gene STARR-seq mESC enhancer starr_37828 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_37829 Neighboring gene STARR-seq mESC enhancer starr_37830 Neighboring gene STARR-seq mESC enhancer starr_37831 Neighboring gene STARR-seq mESC enhancer starr_37832 Neighboring gene STARR-seq mESC enhancer starr_37833 Neighboring gene STARR-seq mESC enhancer starr_37834 Neighboring gene STARR-seq mESC enhancer starr_37835 Neighboring gene complement component 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
    Names
    somatic-type succinyl-CoA:3-oxoacid CoA-transferase
    succinyl-CoA:3-ketoacid CoA transferase
    succinyl-CoA:3-oxoacid CoA transferase
    NP_077150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024188.6NP_077150.1  succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_077150.1

      Status: VALIDATED

      Source sequence(s)
      AK078086, AK151662, AK167681, BE952161
      Consensus CDS
      CCDS27361.1
      UniProtKB/Swiss-Prot
      Q3TIW6, Q9CV92, Q9D0K2
      UniProtKB/TrEMBL
      Q3U9P7, Q3UK61
      Related
      ENSMUSP00000106318.3, ENSMUST00000110690.9
      Conserved Domains (3) summary
      COG1788
      Location:41274
      AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
      COG4670
      Location:48517
      YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]
      cl00339
      Location:300508
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      4055910..4184826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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