Stx18 syntaxin 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx18provided by MGI
Official Full Name: syntaxin 18provided by MGI
Primary source: MGI:MGI:1918366
See related: Ensembl:ENSMUSG00000029125 AllianceGenome:MGI:1918366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810035L21Rik; 4933425D03Rik
Summary: Enables protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of ER to Golgi vesicle-mediated transport; regulation of organelle organization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 18.0), CNS E18 (RPKM 17.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 20.21 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (38194073..38295114)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (38036729..38137770)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis.
Title: Sec22b is a negative regulator of phagocytosis in macrophages.
Syntaxin 18 is involved in endoplasmic reticulum (ER)-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER and plasma or phagosomal membranes.
Title: Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Dmo2 (e-PCR), detects polymorphism
- UniSTS:233990

AU041562 (e-PCR)
- UniSTS:159368

RH124640 (e-PCR)
- UniSTS:161462

RH125737 (e-PCR)
- UniSTS:142567

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum membrane organization	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ER to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ER to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of organelle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: syntaxin-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289535.1 → NP_001276464.1 syntaxin-18 isoform 2

See identical proteins and their annotated locations for NP_001276464.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC115931, AK007700, AK169273, BY037320

Consensus CDS

CCDS71583.1

UniProtKB/Swiss-Prot

Q8VDS8

Related

ENSMUSP00000031008.7, ENSMUST00000031008.13

Conserved Domains (2) summary

cd15850
Location:245 → 303

SNARE_syntaxin18; SNARE motif, subgroup Qa

pfam10496
Location:4 → 96

Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus
NM_001289536.1 → NP_001276465.1 syntaxin-18 isoform 3

See identical proteins and their annotated locations for NP_001276465.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC115931, AC121811

Consensus CDS

CCDS80270.1

UniProtKB/Swiss-Prot

Q8VDS8

Related

ENSMUSP00000038205.9, ENSMUST00000042146.15

Conserved Domains (2) summary

cd15850
Location:219 → 277

SNARE_syntaxin18; SNARE motif, subgroup Qa

pfam10496
Location:4 → 96

Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus
NM_001359398.1 → NP_001346327.1 syntaxin-18 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC115931, AC121811

UniProtKB/TrEMBL

D3YY98

Related

ENSMUSP00000118218.2, ENSMUST00000154929.5

Conserved Domains (1) summary

cd15850
Location:191 → 249

SNARE_syntaxin18; SNARE motif, subgroup Qa
NM_026959.3 → NP_081235.2 syntaxin-18 isoform 1

See identical proteins and their annotated locations for NP_081235.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC115931, AK169273, BY037320

Consensus CDS

CCDS19250.1

UniProtKB/Swiss-Prot

Q3TDJ0, Q8VDS8, Q9D8T6

Related

ENSMUSP00000109761.3, ENSMUST00000114126.9

Conserved Domains (2) summary

cd15850
Location:245 → 303

SNARE_syntaxin18; SNARE motif, subgroup Qa

pfam10496
Location:4 → 96

Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

38194073..38295114

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254807.1 → XP_030110667.1 syntaxin-18 isoform X1

UniProtKB/TrEMBL

D3YY98

Conserved Domains (1) summary

cd15850
Location:191 → 249

SNARE_syntaxin18; SNARE motif, subgroup Qa
XM_006504112.5 → XP_006504175.1 syntaxin-18 isoform X2

UniProtKB/TrEMBL

D3YY98

Conserved Domains (1) summary

cd15850
Location:164 → 222

SNARE_syntaxin18; SNARE motif, subgroup Qa