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    Slc25a27 solute carrier family 25, member 27 [ Mus musculus (house mouse) ]

    Gene ID: 74011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc25a27provided by MGI
    Official Full Name
    solute carrier family 25, member 27provided by MGI
    Primary source
    MGI:MGI:1921261
    See related
    Ensembl:ENSMUSG00000023912 AllianceGenome:MGI:1921261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ucp4; UCP 4; 3632410G24Rik; 9430092A03Rik; D530043E16Rik
    Summary
    Predicted to enable chloride transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial inner membrane. Is expressed in central nervous system; neural retina; peripheral nervous system ganglion; and trigeminal nerve. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 9.6), CNS E18 (RPKM 8.3) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc25a27 in Genome Data Viewer
    Location:
    17 B3; 17 19.75 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43948630..43978105, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43637739..43667214, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Neighboring gene RIKEN cDNA 1700071M16 gene Neighboring gene STARR-seq mESC enhancer starr_42598 Neighboring gene tudor domain containing 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43782177-43782395 Neighboring gene cytochrome P450, family 39, subfamily a, polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43837943-43838243 Neighboring gene predicted gene, 25783 Neighboring gene STARR-seq mESC enhancer starr_42600 Neighboring gene STARR-seq mESC enhancer starr_42601 Neighboring gene predicted gene, 41581

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in apical part of cell  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in neuron projection  
    located_in neuronal cell body  

    General protein information

    Preferred Names
    mitochondrial uncoupling protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357122.1NP_001344051.1  mitochondrial uncoupling protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154647, AU254602
      UniProtKB/TrEMBL
      Q9CX10
      Conserved Domains (1) summary
      pfam00153
      Location:122218
      Mito_carr; Mitochondrial carrier protein
    2. NM_001357123.1NP_001344052.1  mitochondrial uncoupling protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154647, AU254602
      Conserved Domains (1) summary
      pfam00153
      Location:136232
      Mito_carr; Mitochondrial carrier protein
    3. NM_028711.4NP_082987.1  mitochondrial uncoupling protein 4 isoform 1

      See identical proteins and their annotated locations for NP_082987.1

      Status: VALIDATED

      Source sequence(s)
      AC154647, AK043831, AU254602
      Consensus CDS
      CCDS28798.1
      UniProtKB/Swiss-Prot
      Q9D6D0
      UniProtKB/TrEMBL
      Q9CX10
      Related
      ENSMUSP00000024705.5, ENSMUST00000024705.6
      Conserved Domains (2) summary
      PTZ00169
      Location:22316
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:122218
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43948630..43978105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250096.1XP_030105956.1  mitochondrial uncoupling protein 4 isoform X10

      Conserved Domains (1) summary
      pfam00153
      Location:20114
      Mito_carr; Mitochondrial carrier protein
    2. XM_030250101.2XP_030105961.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:798
      Mito_carr; Mitochondrial carrier protein
    3. XM_030250100.1XP_030105960.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:798
      Mito_carr; Mitochondrial carrier protein
    4. XM_030250091.2XP_030105951.1  mitochondrial uncoupling protein 4 isoform X6

      Conserved Domains (1) summary
      pfam00153
      Location:77171
      Mito_carr; Mitochondrial carrier protein
    5. XM_017317679.3XP_017173168.1  mitochondrial uncoupling protein 4 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:138232
      Mito_carr; Mitochondrial carrier protein
    6. XM_030250102.1XP_030105962.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:798
      Mito_carr; Mitochondrial carrier protein
    7. XM_006525001.4XP_006525064.1  mitochondrial uncoupling protein 4 isoform X3

      UniProtKB/TrEMBL
      Q9CX10
      Conserved Domains (1) summary
      pfam00153
      Location:124218
      Mito_carr; Mitochondrial carrier protein
    8. XM_017317681.3XP_017173170.1  mitochondrial uncoupling protein 4 isoform X5

      Conserved Domains (1) summary
      pfam00153
      Location:77171
      Mito_carr; Mitochondrial carrier protein
    9. XM_030250095.2XP_030105955.1  mitochondrial uncoupling protein 4 isoform X10

      Conserved Domains (1) summary
      pfam00153
      Location:20114
      Mito_carr; Mitochondrial carrier protein
    10. XM_030250103.2XP_030105963.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:798
      Mito_carr; Mitochondrial carrier protein
    11. XM_030250099.2XP_030105959.1  mitochondrial uncoupling protein 4 isoform X12

      Conserved Domains (1) summary
      pfam00153
      Location:798
      Mito_carr; Mitochondrial carrier protein
    12. XM_017317678.3XP_017173167.1  mitochondrial uncoupling protein 4 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:138232
      Mito_carr; Mitochondrial carrier protein
    13. XM_030250092.2XP_030105952.1  mitochondrial uncoupling protein 4 isoform X8

      Conserved Domains (1) summary
      pfam00153
      Location:20114
      Mito_carr; Mitochondrial carrier protein
    14. XM_036160809.1XP_036016702.1  mitochondrial uncoupling protein 4 isoform X4

      Conserved Domains (1) summary
      pfam00153
      Location:119215
      Mito_carr; Mitochondrial carrier protein
    15. XM_030250098.2XP_030105958.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:298
      Mito_carr; Mitochondrial carrier protein
    16. XM_036160814.1XP_036016707.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:298
      Mito_carr; Mitochondrial carrier protein
    17. XM_036160812.1XP_036016705.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:298
      Mito_carr; Mitochondrial carrier protein
    18. XM_030250094.2XP_030105954.1  mitochondrial uncoupling protein 4 isoform X9

      Conserved Domains (1) summary
      pfam00153
      Location:20114
      Mito_carr; Mitochondrial carrier protein
    19. XM_036160813.1XP_036016706.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:298
      Mito_carr; Mitochondrial carrier protein
    20. XM_030250093.2XP_030105953.1  mitochondrial uncoupling protein 4 isoform X9

      Conserved Domains (1) summary
      pfam00153
      Location:20114
      Mito_carr; Mitochondrial carrier protein
    21. XM_036160811.1XP_036016704.1  mitochondrial uncoupling protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00153
      Location:298
      Mito_carr; Mitochondrial carrier protein
    22. XM_017317682.3XP_017173171.1  mitochondrial uncoupling protein 4 isoform X7

      Conserved Domains (1) summary
      pfam00153
      Location:138232
      Mito_carr; Mitochondrial carrier protein

    RNA

    1. XR_003952195.2 RNA Sequence

    2. XR_004939591.1 RNA Sequence

    3. XR_004939590.1 RNA Sequence

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