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    Urod uroporphyrinogen decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 22275, updated on 9-Dec-2024

    Summary

    Official Symbol
    Urodprovided by MGI
    Official Full Name
    uroporphyrinogen decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:98916
    See related
    Ensembl:ENSMUSG00000028684 AllianceGenome:MGI:98916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UPD; Uro-d
    Summary
    This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in liver E14.5 (RPKM 225.2), liver E14 (RPKM 197.6) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Urod in Genome Data Viewer
    Location:
    4 D1; 4 53.41 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116847161..116851561, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116989965..116994436, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 5 Neighboring gene predicted gene, 22092 Neighboring gene general transcription factor IIB pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116666946-116667171 Neighboring gene HECT domain E3 ubiquitin protein ligase 3 Neighboring gene tetraspanin 17 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables uroporphyrinogen decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables uroporphyrinogen decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables uroporphyrinogen decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables uroporphyrinogen decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    uroporphyrinogen decarboxylase
    NP_001412793.1
    NP_001412794.1
    NP_001412795.1
    NP_001412796.1
    NP_001412797.1
    NP_001412798.1
    NP_001412799.1
    NP_001412800.1
    NP_001412801.1
    NP_001412802.1
    NP_033504.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425864.1NP_001412793.1  uroporphyrinogen decarboxylase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL671671
    2. NM_001425865.1NP_001412794.1  uroporphyrinogen decarboxylase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL671671
    3. NM_001425866.1NP_001412795.1  uroporphyrinogen decarboxylase isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL671671
    4. NM_001425867.1NP_001412796.1  uroporphyrinogen decarboxylase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL671671
    5. NM_001425868.1NP_001412797.1  uroporphyrinogen decarboxylase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL671671
    6. NM_001425869.1NP_001412798.1  uroporphyrinogen decarboxylase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL671671
    7. NM_001425870.1NP_001412799.1  uroporphyrinogen decarboxylase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL671671
    8. NM_001425871.1NP_001412800.1  uroporphyrinogen decarboxylase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL671671
    9. NM_001425872.1NP_001412801.1  uroporphyrinogen decarboxylase isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL671671
    10. NM_001425873.1NP_001412802.1  uroporphyrinogen decarboxylase isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL671671
    11. NM_009478.5NP_033504.2  uroporphyrinogen decarboxylase isoform 1

      See identical proteins and their annotated locations for NP_033504.2

      Status: REVIEWED

      Source sequence(s)
      AL671671
      Consensus CDS
      CCDS18521.1
      UniProtKB/Swiss-Prot
      P70697, Q91VW4
      Related
      ENSMUSP00000030446.9, ENSMUST00000030446.15
      Conserved Domains (1) summary
      cd00717
      Location:20359
      URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116847161..116851561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)