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    Cpt2 carnitine palmitoyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12896, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cpt2provided by MGI
    Official Full Name
    carnitine palmitoyltransferase 2provided by MGI
    Primary source
    MGI:MGI:109176
    See related
    Ensembl:ENSMUSG00000028607 AllianceGenome:MGI:109176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CPTII
    Summary
    Predicted to enable carnitine O-palmitoyltransferase activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within in utero embryonic development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 110.0), duodenum adult (RPKM 94.1) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Cpt2 in Genome Data Viewer
    Location:
    4 C7; 4 50.18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107761179..107780786, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107903982..107923589, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4643 Neighboring gene mago homolog, exon junction complex core component Neighboring gene STARR-positive B cell enhancer ABC_E1649 Neighboring gene CXXC motif containing zinc binding protein Neighboring gene predicted gene, 40221 Neighboring gene RIKEN cDNA 4930407G08 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity  
    enables acyltransferase activity  
    enables carnitine O-octanoyltransferase activity  
    enables carnitine O-palmitoyltransferase activity  
    enables carnitine O-palmitoyltransferase activity  
    enables carnitine O-palmitoyltransferase activity  
    Process Evidence Code Pubs
    involved_in carnitine metabolic process  
    involved_in carnitine metabolic process  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in long-chain fatty acid metabolic process  
    involved_in long-chain fatty acid metabolic process  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    carnitine O-palmitoyltransferase 2, mitochondrial
    Names
    carnitine palmitoyltransferase II
    NP_034079.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009949.3NP_034079.2  carnitine O-palmitoyltransferase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_034079.2

      Status: VALIDATED

      Source sequence(s)
      AL611936
      Consensus CDS
      CCDS18443.1
      UniProtKB/Swiss-Prot
      P52825, Q3TFS0
      UniProtKB/TrEMBL
      Q3UN55
      Related
      ENSMUSP00000030345.9, ENSMUST00000030345.15
      Conserved Domains (1) summary
      pfam00755
      Location:49648
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107761179..107780786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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