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    Carmil1 capping protein regulator and myosin 1 linker 1 [ Mus musculus (house mouse) ]

    Gene ID: 68732, updated on 9-Dec-2024

    Summary

    Official Symbol
    Carmil1provided by MGI
    Official Full Name
    capping protein regulator and myosin 1 linker 1provided by MGI
    Primary source
    MGI:MGI:1915982
    See related
    Ensembl:ENSMUSG00000021338 AllianceGenome:MGI:1915982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CARMIL; CARML1; Lrrc16; Lrrc16a; D130057M20; 1110037D04Rik
    Summary
    Involved in several processes, including positive regulation of lamellipodium organization; positive regulation of substrate adhesion-dependent cell spreading; and positive regulation of supramolecular fiber organization. Located in lamellipodium. Part of filamentous actin. Is expressed in palatal shelf; skeleton; telencephalon; and vibrissa. Orthologous to human CARMIL1 (capping protein regulator and myosin 1 linker 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.6), CNS E18 (RPKM 3.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Carmil1 in Genome Data Viewer
    Location:
    13 A3.1; 13 10.05 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24196464..24464983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24012481..24280802, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33516 Neighboring gene H2A clustered histone 1 Neighboring gene STARR-seq mESC enhancer starr_33976 Neighboring gene secretagogin, EF-hand calcium binding protein Neighboring gene STARR-seq mESC enhancer starr_33977 Neighboring gene STARR-seq mESC enhancer starr_33978 Neighboring gene STARR-seq mESC enhancer starr_33979 Neighboring gene predicted gene, 33573 Neighboring gene STARR-seq mESC enhancer starr_33980 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 23340 Neighboring gene ribosomal protein L27a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in actin filament network formation  
    involved_in actin filament network formation  
    involved_in barbed-end actin filament uncapping PubMed 
    involved_in cell migration  
    involved_in cell migration  
    involved_in cell migration  
    involved_in establishment or maintenance of cell polarity  
    involved_in lamellipodium assembly  
    involved_in lamellipodium assembly  
    involved_in macropinocytosis  
    involved_in macropinocytosis  
    involved_in negative regulation of barbed-end actin filament capping PubMed 
    involved_in positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of lamellipodium organization PubMed 
    involved_in positive regulation of lamellipodium organization  
    involved_in positive regulation of stress fiber assembly PubMed 
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of substrate adhesion-dependent cell spreading PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation  
    involved_in ruffle organization  
    involved_in ruffle organization  
    involved_in urate metabolic process  
    involved_in urate metabolic process  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in cell leading edge  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    part_of filamentous actin PubMed 
    located_in intermediate filament cytoskeleton  
    is_active_in lamellipodium  
    located_in lamellipodium PubMed 
    located_in lamellipodium  
    located_in lamellipodium  
    located_in macropinosome  
    located_in macropinosome  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    F-actin-uncapping protein LRRC16A
    Names
    CARMIL homolog
    capping protein regulator and myosin 1 linker protein 1
    capping protein, Arp2/3 and myosin-I linker homolog 1
    capping protein, Arp2/3 and myosin-I linker protein 1
    leucine rich repeat containing 16
    leucine rich repeat containing 16A
    leucine-rich repeat-containing protein 16A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311122.1NP_001298051.1  F-actin-uncapping protein LRRC16A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region and contains an alternate 3' exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL590864, AL606464, AL683873
      Consensus CDS
      CCDS79171.1
      UniProtKB/TrEMBL
      D3Z030
      Related
      ENSMUSP00000106028.3, ENSMUST00000110398.8
      Conserved Domains (5) summary
      PHA02682
      Location:11091314
      PHA02682; ORF080 virion core protein; Provisional
      COG4886
      Location:312581
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:281595
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7861076
      CARMIL_C; CARMIL C-terminus
    2. NM_001384122.1NP_001371051.1  F-actin-uncapping protein LRRC16A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL590864, AL606464, AL683873
      Conserved Domains (5) summary
      PHA02682
      Location:11091314
      PHA02682; ORF080 virion core protein; Provisional
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7861076
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:281595
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. NM_026825.3NP_081101.3  F-actin-uncapping protein LRRC16A isoform 1

      See identical proteins and their annotated locations for NP_081101.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK004138, AK043591, AK051570, AY437876
      Consensus CDS
      CCDS36621.1
      UniProtKB/Swiss-Prot
      Q5NCM0, Q6EDY6, Q8BQ45, Q8BRS5, Q91YZ6
      Related
      ENSMUSP00000072662.6, ENSMUST00000072889.12
      Conserved Domains (6) summary
      PHA02682
      Location:11131318
      PHA02682; ORF080 virion core protein; Provisional
      COG4886
      Location:312585
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901080
      CARMIL_C; CARMIL C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      24196464..24464983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315585.3XP_017171074.1  F-actin-uncapping protein LRRC16A isoform X7

      Conserved Domains (5) summary
      PHA03307
      Location:9971384
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7861075
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:281595
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_011244335.4XP_011242637.1  F-actin-uncapping protein LRRC16A isoform X3

      Conserved Domains (5) summary
      PHA02682
      Location:11151320
      PHA02682; ORF080 virion core protein; Provisional
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7861081
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:281595
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_017315584.3XP_017171073.1  F-actin-uncapping protein LRRC16A isoform X5

      Conserved Domains (6) summary
      PHA03307
      Location:10011388
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901079
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_017315586.3XP_017171075.1  F-actin-uncapping protein LRRC16A isoform X11

      Conserved Domains (6) summary
      PHA02682
      Location:11131318
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901079
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    5. XM_011244340.4XP_011242642.1  F-actin-uncapping protein LRRC16A isoform X12

      Conserved Domains (6) summary
      PHA03307
      Location:10071323
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901085
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    6. XM_011244336.4XP_011242638.1  F-actin-uncapping protein LRRC16A isoform X8

      Conserved Domains (6) summary
      PHA02682
      Location:11191324
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901085
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    7. XM_011244334.4XP_011242636.1  F-actin-uncapping protein LRRC16A isoform X2

      Conserved Domains (6) summary
      PHA03307
      Location:10071394
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901085
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    8. XM_011244333.4XP_011242635.1  F-actin-uncapping protein LRRC16A isoform X1

      Conserved Domains (6) summary
      PHA02682
      Location:11191324
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901085
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    9. XM_011244338.4XP_011242640.1  F-actin-uncapping protein LRRC16A isoform X10

      See identical proteins and their annotated locations for XP_011242640.1

      UniProtKB/Swiss-Prot
      Q6EDY6
      Conserved Domains (6) summary
      PHA02682
      Location:11191324
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901085
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    10. XM_036158147.1XP_036014040.1  F-actin-uncapping protein LRRC16A isoform X9

      Conserved Domains (6) summary
      PHA02682
      Location:10361241
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:165192
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:224255
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7071003
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:136
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:146290
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    11. XM_011244337.4XP_011242639.1  F-actin-uncapping protein LRRC16A isoform X9

      Conserved Domains (6) summary
      PHA02682
      Location:10361241
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:165192
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:224255
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7071003
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:136
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:146290
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    12. XM_036158148.1XP_036014041.1  F-actin-uncapping protein LRRC16A isoform X14

      Conserved Domains (5) summary
      PHA03307
      Location:9971313
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7861076
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:281595
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    13. XM_006516741.4XP_006516804.1  F-actin-uncapping protein LRRC16A isoform X6

      Conserved Domains (5) summary
      PHA02682
      Location:11091314
      PHA02682; ORF080 virion core protein; Provisional
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7861075
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:281595
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    14. XM_030247393.2XP_030103253.1  F-actin-uncapping protein LRRC16A isoform X13

      Conserved Domains (6) summary
      PHA03307
      Location:10011317
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901079
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    15. XM_006516739.4XP_006516802.1  F-actin-uncapping protein LRRC16A isoform X4

      Conserved Domains (6) summary
      PHA02682
      Location:11131318
      PHA02682; ORF080 virion core protein; Provisional
      sd00031
      Location:248275
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307338
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16000
      Location:7901079
      CARMIL_C; CARMIL C-terminus
      pfam17888
      Location:38119
      Carm_PH; Carmil pleckstrin homology domain
      cl39015
      Location:229373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RNA

    1. XR_001780807.3 RNA Sequence

    2. XR_001780806.3 RNA Sequence

    3. XR_001780808.3 RNA Sequence

    4. XR_001780812.3 RNA Sequence

    5. XR_004938063.1 RNA Sequence

    6. XR_001780810.3 RNA Sequence

    7. XR_001780811.3 RNA Sequence

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