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    Aak1 AP2 associated kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 269774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aak1provided by MGI
    Official Full Name
    AP2 associated kinase 1provided by MGI
    Primary source
    MGI:MGI:1098687
    See related
    Ensembl:ENSMUSG00000057230 AllianceGenome:MGI:1098687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm38495; mKIAA1048; 9630042K20; D6Ertd245e; 5530400K14Rik
    Summary
    Predicted to enable AP-2 adaptor complex binding activity; Notch binding activity; and protein serine/threonine kinase activity. Involved in presynaptic endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; clathrin-coated vesicle; and terminal bouton. Predicted to be part of clathrin complex. Predicted to be active in calyx of Held. Is expressed in cranial ganglion; dorsal root ganglion; retina nuclear layer; and telencephalon. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 16.3), cortex adult (RPKM 15.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aak1 in Genome Data Viewer
    Location:
    6 D1; 6 37.75 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86826252..86980209)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86849274..87003227)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene germ cell-less, spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene annexin A4 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene STARR-positive B cell enhancer ABC_E9670 Neighboring gene STARR-positive B cell enhancer ABC_E8113 Neighboring gene STARR-seq mESC enhancer starr_16545 Neighboring gene STARR-positive B cell enhancer ABC_E6452 Neighboring gene NFU1 iron-sulfur cluster scaffold Neighboring gene STARR-seq mESC enhancer starr_16547 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:87025148-87025378 Neighboring gene glutamine fructose-6-phosphate transaminase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel AP-2 adaptor interaction motif initially identified in the long-splice isoform of synaptojanin 1, SJ170. Jha A, et al. J Biol Chem, 2004 Jan 16. PMID 14565955
    2. Periodic Variation of AAK1 in an Aβ(1-42)-Induced Mouse Model of Alzheimer's Disease. Fu X, et al. J Mol Neurosci, 2018 Jun. PMID 29774516
    3. Dynamic landscape of alternative polyadenylation during retinal development. Hu W, et al. Cell Mol Life Sci, 2017 May. PMID 27990575, Free PMC Article
    4. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33376223, Free PMC Article
    5. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40785

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AP-2 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AP-2 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables AP-2 adaptor complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Notch binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in presynaptic endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of clathrin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal bouton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    AP2-associated protein kinase 1
    Names
    adaptor-associated kinase 1
    NP_001035195.1
    NP_001365581.1
    NP_001365583.1
    NP_001365584.1
    NP_808430.2
    XP_006506255.1
    XP_017177086.1
    XP_030111273.1
    XP_030111275.1
    XP_030111276.1
    XP_030111278.1
    XP_036022028.1
    XP_036022029.1
    XP_036022030.1
    XP_036022031.1
    XP_036022032.1
    XP_036022033.1
    XP_036022034.1
    XP_036022035.1
    XP_036022036.1
    XP_036022037.1
    XP_036022038.1
    XP_036022039.1
    XP_036022040.1
    XP_036022041.1
    XP_036022042.1
    XP_036022043.1
    XP_036022044.1
    XP_036022045.1
    XP_036022046.1
    XP_036022047.1
    XP_036022048.1
    XP_036022049.1
    XP_036022050.1
    XP_036022051.1
    XP_036022052.1
    XP_036022053.1
    XP_036022054.1
    XP_036022055.1
    XP_036022056.1
    XP_036022057.1
    XP_036022058.1
    XP_036022059.1
    XP_036022060.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040106.3 → NP_001035195.1  AP2-associated protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_001035195.1

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC159712
      Consensus CDS
      CCDS39544.1
      UniProtKB/Swiss-Prot
      B2RUJ0, Q3TY53, Q3UHJ0, Q6ZPZ6, Q80XP6
      Related
      ENSMUSP00000086948.7, ENSMUST00000089519.13
      Conserved Domains (2) summary
      smart00220
      Location:47 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    2. NM_001378652.1 → NP_001365581.1  AP2-associated protein kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC159712
      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:910 → 1122
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    3. NM_001378654.1 → NP_001365583.1  AP2-associated protein kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC159712
      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:910 → 1122
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    4. NM_001378655.1 → NP_001365584.1  AP2-associated protein kinase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC159712
      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 541
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:829 → 1041
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    5. NM_177762.7 → NP_808430.2  AP2-associated protein kinase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC159712
      Consensus CDS
      CCDS20317.1
      UniProtKB/Swiss-Prot
      Q3UHJ0
      Related
      ENSMUSP00000003710.10, ENSMUST00000003710.10
      Conserved Domains (2) summary
      smart00220
      Location:47 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86826252..86980209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166138.1 → XP_036022031.1  AP2-associated protein kinase 1 isoform X1

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1085 → 1297
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    2. XM_036166152.1 → XP_036022045.1  AP2-associated protein kinase 1 isoform X13

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 541
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:971 → 1183
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    3. XM_036166137.1 → XP_036022030.1  AP2-associated protein kinase 1 isoform X1

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1085 → 1297
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    4. XM_036166157.1 → XP_036022050.1  AP2-associated protein kinase 1 isoform X17

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:942 → 1154
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    5. XM_036166163.1 → XP_036022056.1  AP2-associated protein kinase 1 isoform X22

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 541
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:829 → 1041
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    6. XM_036166165.1 → XP_036022058.1  AP2-associated protein kinase 1 isoform X27

      Conserved Domains (3) summary
      PHA03247
      Location:320 → 693
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    7. XM_030255418.2 → XP_030111278.1  AP2-associated protein kinase 1 isoform X31

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 541
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    8. XM_036166136.1 → XP_036022029.1  AP2-associated protein kinase 1 isoform X1

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1085 → 1297
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    9. XM_036166149.1 → XP_036022042.1  AP2-associated protein kinase 1 isoform X10

      Conserved Domains (4) summary
      PHA03247
      Location:320 → 693
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:977 → 1189
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    10. XM_036166146.1 → XP_036022039.1  AP2-associated protein kinase 1 isoform X8

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 542
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1004 → 1216
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    11. XM_036166139.1 → XP_036022032.1  AP2-associated protein kinase 1 isoform X2

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1084 → 1296
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    12. XM_006506192.3 → XP_006506255.1  AP2-associated protein kinase 1 isoform X24

      Conserved Domains (2) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    13. XM_036166135.1 → XP_036022028.1  AP2-associated protein kinase 1 isoform X1

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1085 → 1297
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    14. XM_036166144.1 → XP_036022037.1  AP2-associated protein kinase 1 isoform X7

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1011 → 1223
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    15. XM_036166141.1 → XP_036022034.1  AP2-associated protein kinase 1 isoform X4

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1051 → 1263
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    16. XM_036166148.1 → XP_036022041.1  AP2-associated protein kinase 1 isoform X10

      Conserved Domains (4) summary
      PHA03247
      Location:320 → 693
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:977 → 1189
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    17. XM_036166155.1 → XP_036022048.1  AP2-associated protein kinase 1 isoform X16

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:943 → 1155
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    18. XM_036166140.1 → XP_036022033.1  AP2-associated protein kinase 1 isoform X3

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1053 → 1265
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    19. XM_036166143.1 → XP_036022036.1  AP2-associated protein kinase 1 isoform X6

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1019 → 1231
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    20. XM_036166153.1 → XP_036022046.1  AP2-associated protein kinase 1 isoform X14

      Conserved Domains (4) summary
      PHA03247
      Location:320 → 693
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:945 → 1157
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    21. XM_036166158.1 → XP_036022051.1  AP2-associated protein kinase 1 isoform X18

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:911 → 1123
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    22. XM_030255416.2 → XP_030111276.1  AP2-associated protein kinase 1 isoform X27

      Conserved Domains (3) summary
      PHA03247
      Location:320 → 693
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    23. XM_030255413.2 → XP_030111273.1  AP2-associated protein kinase 1 isoform X25

      Conserved Domains (3) summary
      PHA03247
      Location:320 → 693
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    24. XM_036166147.1 → XP_036022040.1  AP2-associated protein kinase 1 isoform X9

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 541
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1003 → 1215
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    25. XM_017321597.2 → XP_017177086.1  AP2-associated protein kinase 1 isoform X29

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 541
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    26. XM_036166151.1 → XP_036022044.1  AP2-associated protein kinase 1 isoform X12

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 542
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:972 → 1184
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    27. XM_036166145.1 → XP_036022038.1  AP2-associated protein kinase 1 isoform X8

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 542
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1004 → 1216
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    28. XM_036166160.1 → XP_036022053.1  AP2-associated protein kinase 1 isoform X20

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 542
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:862 → 1074
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    29. XM_036166159.1 → XP_036022052.1  AP2-associated protein kinase 1 isoform X19

      Conserved Domains (4) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 542
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:864 → 1076
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    30. XM_036166167.1 → XP_036022060.1  AP2-associated protein kinase 1 isoform X30

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      PRK10263
      Location:335 → 542
      PRK10263; DNA translocase FtsK; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    31. XM_036166162.1 → XP_036022055.1  AP2-associated protein kinase 1 isoform X21

      Conserved Domains (3) summary
      PHA03247
      Location:91 → 464
      PHA03247; large tegument protein UL36; Provisional
      pfam15282
      Location:856 → 1068
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
      cl21453
      Location:1 → 87
      PKc_like; Protein Kinases, catalytic domain

    32. XM_036166142.1 → XP_036022035.1  AP2-associated protein kinase 1 isoform X5

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:1050 → 1262
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    33. XM_036166150.1 → XP_036022043.1  AP2-associated protein kinase 1 isoform X11

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:976 → 1188
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    34. XM_036166156.1 → XP_036022049.1  AP2-associated protein kinase 1 isoform X17

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:942 → 1154
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    35. XM_036166154.1 → XP_036022047.1  AP2-associated protein kinase 1 isoform X15

      Conserved Domains (3) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:944 → 1156
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    36. XM_036166161.1 → XP_036022054.1  AP2-associated protein kinase 1 isoform X21

      Conserved Domains (3) summary
      PHA03247
      Location:91 → 464
      PHA03247; large tegument protein UL36; Provisional
      pfam15282
      Location:856 → 1068
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
      cl21453
      Location:1 → 87
      PKc_like; Protein Kinases, catalytic domain

    37. XM_036166164.1 → XP_036022057.1  AP2-associated protein kinase 1 isoform X23

      Conserved Domains (2) summary
      pfam15282
      Location:775 → 987
      BMP2K_C; BMP-2-inducible protein kinase C-terminus
      cl21453
      Location:1 → 87
      PKc_like; Protein Kinases, catalytic domain

    38. XM_030255415.2 → XP_030111275.1  AP2-associated protein kinase 1 isoform X26

      Conserved Domains (2) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    39. XM_036166166.1 → XP_036022059.1  AP2-associated protein kinase 1 isoform X28

      Conserved Domains (2) summary
      PHA03378
      Location:296 → 429
      PHA03378; EBNA-3B; Provisional
      cd14037
      Location:42 → 316
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHJ0.2 GenPept UniProtKB/Swiss-Prot:Q3UHJ0
    Q6PIU9.2 GenPept UniProtKB/Swiss-Prot:Q6PIU9

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