Arhgef10l Rho guanine nucleotide exchange factor 10-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgef10lprovided by MGI
Official Full Name: Rho guanine nucleotide exchange factor 10-likeprovided by MGI
Primary source: MGI:MGI:1920004
See related: Ensembl:ENSMUSG00000040964 AllianceGenome:MGI:1920004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810441C07Rik
Summary: Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in SREBP signaling pathway; actin cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in cytosol. Is expressed in brain; facial prominence ectoderm; facial prominence mesenchyme; liver; and testis. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to human ARHGEF10L (Rho guanine nucleotide exchange factor 10 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 18.8), ovary adult (RPKM 14.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 71.58 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (140241796..140393318, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (140514485..140666007, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigating the effect of ARHGEF10L gene on tumor growth in gastric cancer in a nude mouse model using quantitative MRI parameters.
Title: Investigating the effect of ARHGEF10L gene on tumor growth in gastric cancer in a nude mouse model using quantitative MRI parameters.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SREBP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in SREBP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in SREBP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 10-like protein

Names: GrinchGEF; Rho guanine nucleotide exchange factor (GEF) 10-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112722.1 → NP_001106193.1 rho guanine nucleotide exchange factor 10-like protein isoform b

See identical proteins and their annotated locations for NP_001106193.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the 5' coding region, compared to variant 4. It encodes isoform b, which is shorter than isoform d.

Source sequence(s)

AK028570, AK028648, AL954710, BC059220, BY026313

Consensus CDS

CCDS51343.1

UniProtKB/TrEMBL

A2AWP6

Related

ENSMUSP00000066249.6, ENSMUST00000069623.12

Conserved Domains (3) summary

cd00160
Location:276 → 460

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:748 → 1239

WD40_2; WD40 repeated domain

pfam19057
Location:485 → 640

PH_19; PH domain
NM_001112723.1 → NP_001106194.1 rho guanine nucleotide exchange factor 10-like protein isoform c

See identical proteins and their annotated locations for NP_001106194.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the 5' coding region, compared to variant 4. It encodes isoform c, which is shorter than isoform d.

Source sequence(s)

AK028648, AK129408, BC059220

Consensus CDS

CCDS51342.1

UniProtKB/TrEMBL

A2AWP6

Related

ENSMUSP00000095431.3, ENSMUST00000097820.9

Conserved Domains (1) summary

pfam00621
Location:283 → 460

RhoGEF; RhoGEF domain
NM_001290803.1 → NP_001277732.1 rho guanine nucleotide exchange factor 10-like protein isoform d

See identical proteins and their annotated locations for NP_001277732.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).

Source sequence(s)

BB612864, BB842000, BC059220, BQ558784, BX516814, CA751244, CF531696, CF532111, CX564261

Consensus CDS

CCDS71507.1

UniProtKB/Swiss-Prot

A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (3) summary

cd00160
Location:315 → 499

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:787 → 1278

WD40_2; WD40 repeated domain

pfam19057
Location:524 → 679

PH_19; PH domain
NM_172415.3 → NP_766003.3 rho guanine nucleotide exchange factor 10-like protein isoform a

See identical proteins and their annotated locations for NP_766003.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 4. It encodes isoform a, which is shorter than isoform d.

Source sequence(s)

AK129408, BC059220, CF532111

Consensus CDS

CCDS51344.1

UniProtKB/TrEMBL

A2AWP6

Related

ENSMUSP00000040531.4, ENSMUST00000039204.10

Conserved Domains (1) summary

pfam00621
Location:322 → 499

RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

140241796..140393318 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253821.1 → XP_030109681.1 rho guanine nucleotide exchange factor 10-like protein isoform X3

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (1) summary

pfam00621
Location:322 → 499

RhoGEF; RhoGEF domain
XM_030253820.2 → XP_030109680.1 rho guanine nucleotide exchange factor 10-like protein isoform X1

UniProtKB/Swiss-Prot

A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (3) summary

cd00160
Location:315 → 499

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:787 → 1278

WD40_2; WD40 repeated domain

pfam19057
Location:524 → 679

PH_19; PH domain
XM_030253822.1 → XP_030109682.1 rho guanine nucleotide exchange factor 10-like protein isoform X5

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (1) summary

pfam00621
Location:283 → 460

RhoGEF; RhoGEF domain
XM_036164470.1 → XP_036020363.1 rho guanine nucleotide exchange factor 10-like protein isoform X1

UniProtKB/Swiss-Prot

A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (3) summary

cd00160
Location:315 → 499

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:787 → 1278

WD40_2; WD40 repeated domain

pfam19057
Location:524 → 679

PH_19; PH domain
XM_036164471.1 → XP_036020364.1 rho guanine nucleotide exchange factor 10-like protein isoform X4

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (3) summary

cd00160
Location:276 → 460

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:748 → 1239

WD40_2; WD40 repeated domain

pfam19057
Location:485 → 640

PH_19; PH domain
XM_006539202.1 → XP_006539265.1 rho guanine nucleotide exchange factor 10-like protein isoform X1

See identical proteins and their annotated locations for XP_006539265.1

UniProtKB/Swiss-Prot

A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5

UniProtKB/TrEMBL

A2AWP6

Related

ENSMUSP00000101425.2, ENSMUST00000105799.8

Conserved Domains (3) summary

cd00160
Location:315 → 499

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:787 → 1278

WD40_2; WD40 repeated domain

pfam19057
Location:524 → 679

PH_19; PH domain
XM_006539201.5 → XP_006539264.1 rho guanine nucleotide exchange factor 10-like protein isoform X1

See identical proteins and their annotated locations for XP_006539264.1

UniProtKB/Swiss-Prot

A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (3) summary

cd00160
Location:315 → 499

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:787 → 1278

WD40_2; WD40 repeated domain

pfam19057
Location:524 → 679

PH_19; PH domain
XM_017320396.3 → XP_017175885.1 rho guanine nucleotide exchange factor 10-like protein isoform X2

UniProtKB/Swiss-Prot

A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (3) summary

cd00160
Location:315 → 499

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:787 → 1278

WD40_2; WD40 repeated domain

pfam19057
Location:524 → 679

PH_19; PH domain
XM_011250337.4 → XP_011248639.1 rho guanine nucleotide exchange factor 10-like protein isoform X1

See identical proteins and their annotated locations for XP_011248639.1

UniProtKB/Swiss-Prot

A2AWP5, A2AWP8, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5

UniProtKB/TrEMBL

A2AWP6

Conserved Domains (3) summary

cd00160
Location:315 → 499

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:787 → 1278

WD40_2; WD40 repeated domain

pfam19057
Location:524 → 679

PH_19; PH domain
XM_017320397.3 → XP_017175886.1 rho guanine nucleotide exchange factor 10-like protein isoform X7

UniProtKB/TrEMBL

A2AWP6

Related

ENSMUSP00000101423.3, ENSMUST00000105797.9

Conserved Domains (1) summary

pfam00621
Location:105 → 282

RhoGEF; RhoGEF domain
XM_006539204.5 → XP_006539267.1 rho guanine nucleotide exchange factor 10-like protein isoform X6

UniProtKB/TrEMBL

A2AWP6

Related

ENSMUSP00000101424.2, ENSMUST00000105798.8

Conserved Domains (1) summary

cd00160
Location:98 → 282

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.