Abcb9 ATP-binding cassette, sub-family B member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcb9provided by MGI
Official Full Name: ATP-binding cassette, sub-family B member 9provided by MGI
Primary source: MGI:MGI:1861729
See related: Ensembl:ENSMUSG00000029408 AllianceGenome:MGI:1861729
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TAPL; mKIAA1520
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may be associated with lysosome activity. [provided by RefSeq, Jul 2008]
Expression: Broad expression in thymus adult (RPKM 11.0), genital fat pad adult (RPKM 8.2) and 24 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 F; 5 63.36 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (124199920..124234009, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (124061857..124095955, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.
Title: The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4)

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type oligopeptide transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type oligopeptide transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type peptide transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type peptide transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type peptide transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in oligopeptide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in peptide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptide transport	ISO Inferred from Sequence Orthology more info
involved_in peptide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: ABC-type oligopeptide transporter ABCB9

Names: ABC transporter 9 protein; ATP-binding cassette transporter 9; ATP-binding cassette, sub-family B (MDR/TAP), member 9; TAP-like protein; mABCB9

NP_063928.2

EC 7.4.2.6

XP_017176501.1

EC 7.4.2.6

XP_036021222.1

EC 7.4.2.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019875.2 → NP_063928.2 ABC-type oligopeptide transporter ABCB9

See identical proteins and their annotated locations for NP_063928.2

Status: VALIDATED

Source sequence(s)

AC113474, AK044140

Consensus CDS

CCDS19671.1

UniProtKB/Swiss-Prot

Q8CHA1, Q9D212, Q9JIN1, Q9JJ59

Related

ENSMUSP00000031354.5, ENSMUST00000031354.11

Conserved Domains (3) summary

cd03248
Location:489 → 714

ABCC_TAP; ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C

TIGR00958
Location:44 → 734

3a01208; Conjugate Transporter-2 (CT2) Family protein

pfam00664
Location:189 → 451

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

124199920..124234009 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165329.1 → XP_036021222.1 ABC-type oligopeptide transporter ABCB9 isoform X2

Conserved Domains (1) summary

TIGR00958
Location:2 → 444

3a01208; Conjugate Transporter-2 (CT2) Family protein
XM_017321012.1 → XP_017176501.1 ABC-type oligopeptide transporter ABCB9 isoform X1

Conserved Domains (1) summary

TIGR00958
Location:2 → 517

3a01208; Conjugate Transporter-2 (CT2) Family protein