Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ucp1provided by MGI
Official Full Name: uncoupling protein 1 (mitochondrial, proton carrier)provided by MGI
Primary source: MGI:MGI:98894
See related: Ensembl:ENSMUSG00000031710 AllianceGenome:MGI:98894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ucp; Slc25a7
Summary: Enables long-chain fatty acid binding activity; oxidative phosphorylation uncoupler activity; and purine ribonucleotide binding activity. Involved in several processes, including cellular response to cold; diet induced thermogenesis; and positive regulation of cold-induced thermogenesis. Acts upstream of or within brown fat cell differentiation and regulation of transcription by RNA polymerase II. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; adrenal gland; submandibular gland; telencephalon; and thymus. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 353.2), mammary gland adult (RPKM 206.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 39.65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84016977..84025085)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (83290348..83298456)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UCP1-dependent brown adipose activation accelerates cardiac metabolic remodeling and reduces initial hypertrophic and fibrotic responses to pathological stress.
Title: UCP1-dependent brown adipose activation accelerates cardiac metabolic remodeling and reduces initial hypertrophic and fibrotic responses to pathological stress.
Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse UCP1.
Title: Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse UCP1.
Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis.
Title: Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis.
Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity.
Title: Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity.
Differential responses to UCP1 ablation in classical brown versus beige fat, despite a parallel increase in sympathetic innervation.
Title: Differential responses to UCP1 ablation in classical brown versus beige fat, despite a parallel increase in sympathetic innervation.
Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning.
Title: Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning.
Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.
Title: Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.
Suppression of STAT3 phosphorylation in hypothalamus facilitates weight loss via upregulating UCP1.
Title: Suppression of STAT3 phosphorylation in hypothalamus facilitates weight loss via upregulating UCP1.
PPARalpha/gamma synergism activates UCP1-dependent and -independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice.
Title: PPARα/γ synergism activates UCP1-dependent and -independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice.
Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice.
Title: Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice.

Submit: New GeneRIF Correction See all GeneRIFs (207)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (19) 1 citation
Spontaneous (2) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

AI385626 (e-PCR)
- UniSTS:179772

Ucp1 (e-PCR), detects polymorphism
- UniSTS:144726

Ucp1 (e-PCR), detects polymorphism
- UniSTS:547170

Ucp1 (e-PCR), detects polymorphism
- UniSTS:461937

PMC164531P2 (e-PCR)
- UniSTS:271496

Ucp1 (e-PCR), detects polymorphism
- UniSTS:531400

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables cardiolipin binding	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables oxidative phosphorylation uncoupler activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidative phosphorylation uncoupler activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidative phosphorylation uncoupler activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine ribonucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in brown fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cold	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to dehydroepiandrosterone	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diet induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial brown fat uncoupling protein 1

Names: UCP 1; solute carrier family 25 member 7; thermogenin; uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.