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    Sh3d19 SH3 domain protein D19 [ Mus musculus (house mouse) ]

    Gene ID: 27059, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sh3d19provided by MGI
    Official Full Name
    SH3 domain protein D19provided by MGI
    Primary source
    MGI:MGI:1350923
    See related
    Ensembl:ENSMUSG00000028082 AllianceGenome:MGI:1350923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kryn
    Summary
    Predicted to enable proline-rich region binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of membrane protein ectodomain proteolysis; and regulation of cell morphogenesis. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in gut; metanephros; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Orthologous to human SH3D19 (SH3 domain containing 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 21.0), colon adult (RPKM 8.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sh3d19 in Genome Data Viewer
    Location:
    3 F1; 3 37.83 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (85878112..86037833)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (85970805..86130526)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9790 Neighboring gene STARR-seq mESC enhancer starr_08116 Neighboring gene STARR-seq mESC enhancer starr_08117 Neighboring gene predicted gene, 27811 Neighboring gene STARR-seq mESC enhancer starr_08123 Neighboring gene STARR-seq mESC enhancer starr_08124 Neighboring gene serine protease 48 Neighboring gene predicted gene, 25188 Neighboring gene small nucleolar RNA, C/D box U73A Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene ribosomal protein S3A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles. Shimomura Y, et al. J Dermatol Sci, 2003 Feb. PMID 12615363
    2. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Fenske TS, et al. Cancer Res, 2006 May 15. PMID 16707424
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein 19
    Names
    SH3 domain containing protein D 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082414.3 → NP_001075883.3  SH3 domain-containing protein 19 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC133508, AC138528
      Consensus CDS
      CCDS38469.2
      UniProtKB/TrEMBL
      A0A571BGG1
      Related
      ENSMUSP00000158832.2, ENSMUST00000238545.2
      Conserved Domains (4) summary
      cd11814
      Location:635 → 684
      SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
      cd11816
      Location:791 → 841
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:38 → 559
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:715 → 766
      SH3; Src Homology 3 domain superfamily

    2. NM_001374679.1 → NP_001361608.1  SH3 domain-containing protein 19 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC133508, AC138528
      Consensus CDS
      CCDS89646.1
      UniProtKB/TrEMBL
      A0A571BGG1
      Conserved Domains (4) summary
      cd11814
      Location:635 → 684
      SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
      cd11816
      Location:791 → 841
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:38 → 559
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:715 → 766
      SH3; Src Homology 3 domain superfamily

    3. NM_001404299.1 → NP_001391228.1  SH3 domain-containing protein 19 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC133508, AC138528
      UniProtKB/TrEMBL
      A0A571BEF4
      Related
      ENSMUSP00000158699.2, ENSMUST00000238443.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      85878112..86037833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319605.3 → XP_017175094.2  SH3 domain-containing protein 19 isoform X5

      Conserved Domains (2) summary
      PTZ00449
      Location:245 → 666
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03247
      Location:50 → 375
      PHA03247; large tegument protein UL36; Provisional

    2. XM_011240136.4 → XP_011238438.1  SH3 domain-containing protein 19 isoform X4

      See identical proteins and their annotated locations for XP_011238438.1

      UniProtKB/Swiss-Prot
      O08635, O35146, Q8C7I2, Q91X43
      Related
      ENSMUSP00000138320.2, ENSMUST00000182666.8
      Conserved Domains (4) summary
      cd11814
      Location:419 → 468
      SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
      cd11816
      Location:575 → 625
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:25 → 305
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:499 → 550
      SH3; Src Homology 3 domain superfamily

    3. XM_011240135.4 → XP_011238437.1  SH3 domain-containing protein 19 isoform X2

      Conserved Domains (4) summary
      cd11814
      Location:700 → 749
      SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
      cd11816
      Location:856 → 906
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:103 → 624
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:780 → 831
      SH3; Src Homology 3 domain superfamily

    4. XM_006501547.4 → XP_006501610.1  SH3 domain-containing protein 19 isoform X3

      See identical proteins and their annotated locations for XP_006501610.1

      UniProtKB/TrEMBL
      A0A571BGG1
      Conserved Domains (4) summary
      cd11814
      Location:635 → 684
      SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
      cd11816
      Location:791 → 841
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:38 → 559
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:715 → 766
      SH3; Src Homology 3 domain superfamily

    5. XM_006501550.5 → XP_006501613.1  SH3 domain-containing protein 19 isoform X4

      See identical proteins and their annotated locations for XP_006501613.1

      UniProtKB/Swiss-Prot
      O08635, O35146, Q8C7I2, Q91X43
      Related
      ENSMUSP00000158600.2, ENSMUST00000238331.2
      Conserved Domains (4) summary
      cd11814
      Location:419 → 468
      SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
      cd11816
      Location:575 → 625
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:25 → 305
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:499 → 550
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_003954328.2 RNA Sequence

    2. XR_004941332.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012059.2: Suppressed sequence

      Description
      NM_012059.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91X43.2 GenPept UniProtKB/Swiss-Prot:Q91X43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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