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    Ccl12 C-C motif chemokine ligand 12 [ Mus musculus (house mouse) ]

    Gene ID: 20293, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccl12provided by MGI
    Official Full Name
    C-C motif chemokine ligand 12provided by MGI
    Primary source
    MGI:MGI:108224
    See related
    Ensembl:ENSMUSG00000035352 AllianceGenome:MGI:108224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCP-5; Scya12
    Summary
    Enables CCR2 chemokine receptor binding activity. Involved in angiogenesis; inflammatory response; and monocyte chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 5.0), genital fat pad adult (RPKM 3.4) and 22 other tissues See more
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    Genomic context

    See Ccl12 in Genome Data Viewer
    Location:
    11 C; 11 49.9 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (81992671..81994225)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82101845..82103399)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 11 Neighboring gene predicted gene, 38913 Neighboring gene C-C motif chemokine ligand 8 Neighboring gene STARR-seq mESC enhancer starr_30171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:81988408-81988591 Neighboring gene C-C motif chemokine ligand 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR2 chemokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in astrocyte cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of leukocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of natural killer cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    C-C motif chemokine 12
    Names
    MCP-1-related chemokine
    chemokine (C-C motif) ligand 12
    monocyte chemoattractant protein 5
    monocyte chemotactic protein 5
    small-inducible cytokine A12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011331.3NP_035461.2  C-C motif chemokine 12 precursor

      See identical proteins and their annotated locations for NP_035461.2

      Status: VALIDATED

      Source sequence(s)
      AL645596
      Consensus CDS
      CCDS36247.1
      UniProtKB/Swiss-Prot
      Q62401, Q9QYD6
      UniProtKB/TrEMBL
      Q545B5
      Related
      ENSMUSP00000000194.4, ENSMUST00000000194.4
      Conserved Domains (1) summary
      smart00199
      Location:3089
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      81992671..81994225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)