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    Ccl1 C-C motif chemokine ligand 1 [ Mus musculus (house mouse) ]

    Gene ID: 20290, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccl1provided by MGI
    Official Full Name
    C-C motif chemokine ligand 1provided by MGI
    Primary source
    MGI:MGI:98258
    See related
    Ensembl:ENSMUSG00000020702 AllianceGenome:MGI:98258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P500; Tca3; I-309; Scya1; Tca-3
    Summary
    Enables cytokine activity. Involved in cellular response to interleukin-17. Acts upstream of or within chemotaxis. Predicted to be active in extracellular space. Is expressed in heart; late tubule; and testis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple sclerosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human CCL1 (C-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Ccl1 in Genome Data Viewer
    Location:
    11 C; 11 49.99 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82067492..82070638, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82176666..82179812, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 12 Neighboring gene STARR-seq mESC enhancer starr_30171 Neighboring gene C-C motif chemokine ligand 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:81988408-81988591 Neighboring gene STARR-seq mESC enhancer starr_30173 Neighboring gene predicted gene, 38577 Neighboring gene transmembrane protein 132E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interleukin-17 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-C motif chemokine 1
    Names
    CCR8 ligand
    SIS-epsilon
    T-cell activation protein 3
    chemokine (C-C motif) ligand 1
    small-inducible cytokine A1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011329.3NP_035459.1  C-C motif chemokine 1 precursor

      See identical proteins and their annotated locations for NP_035459.1

      Status: VALIDATED

      Source sequence(s)
      M17957
      Consensus CDS
      CCDS36249.1
      UniProtKB/Swiss-Prot
      P10146, P14098, Q9QUR9, Q9QUS5
      UniProtKB/TrEMBL
      Q0VB35
      Related
      ENSMUSP00000103824.3, ENSMUST00000108189.9
      Conserved Domains (1) summary
      smart00199
      Location:3088
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82067492..82070638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)