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    Scg5 secretogranin V [ Mus musculus (house mouse) ]

    Gene ID: 20394, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scg5provided by MGI
    Official Full Name
    secretogranin Vprovided by MGI
    Primary source
    MGI:MGI:98289
    See related
    Ensembl:ENSMUSG00000023236 AllianceGenome:MGI:98289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    7B2; Sgne1; Sgne-1
    Summary
    Enables enzyme inhibitor activity. Involved in intracellular protein transport; peptide hormone processing; and regulation of hormone secretion. Is active in nucleus. Is expressed in several structures, including gut; lung; nervous system; and sensory organ. Used to study pituitary-dependent Cushing's disease. Orthologous to human SCG5 (secretogranin V). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 84.7), cerebellum adult (RPKM 75.9) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Scg5 in Genome Data Viewer
    Location:
    2 E4; 2 57.45 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113606708..113659423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (113776313..113829091, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene gremlin 1, DAN family BMP antagonist Neighboring gene predicted gene, 46756 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113664128-113664429 Neighboring gene Rho GTPase activating protein 11A Neighboring gene STARR-seq mESC enhancer starr_05402 Neighboring gene predicted gene, 30985

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    neuroendocrine protein 7B2
    Names
    secretogranin-5
    secretory granule endocrine protein I
    secretory granule neuroendocrine protein 1, 7B2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420937.1NP_001407866.1  neuroendocrine protein 7B2 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
    2. NM_001420938.1NP_001407867.1  neuroendocrine protein 7B2 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
    3. NM_001420939.1NP_001407868.1  neuroendocrine protein 7B2 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
    4. NM_001420942.1NP_001407871.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
    5. NM_001420943.1NP_001407872.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
    6. NM_001420944.1NP_001407873.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
    7. NM_001420945.1NP_001407874.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
    8. NM_001420946.1NP_001407875.1  neuroendocrine protein 7B2 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
    9. NM_001420947.1NP_001407876.1  neuroendocrine protein 7B2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL772405
    10. NM_009162.4NP_033188.3  neuroendocrine protein 7B2 isoform c precursor

      See identical proteins and their annotated locations for NP_033188.3

      Status: VALIDATED

      Source sequence(s)
      AL772405
      Consensus CDS
      CCDS16561.1
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Related
      ENSMUSP00000024005.8, ENSMUST00000024005.8
      Conserved Domains (1) summary
      pfam05281
      Location:24199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

    RNA

    1. NR_185217.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772405
    2. NR_185218.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772405

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      113606708..113659423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159847.1XP_036015740.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
    2. XM_036159851.1XP_036015744.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
    3. XM_036159848.1XP_036015741.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
    4. XM_036159849.1XP_036015742.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)