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    Rab40c Rab40C, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 224624, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab40cprovided by MGI
    Official Full Name
    Rab40C, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:2183454
    See related
    Ensembl:ENSMUSG00000025730 AllianceGenome:MGI:2183454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAR3
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in exocytosis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endosome; plasma membrane; and synaptic vesicle. Predicted to colocalize with Golgi apparatus and lipid droplet. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human RAB40C (RAB40C, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.2), ovary adult (RPKM 23.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rab40c in Genome Data Viewer
    Location:
    17 A3.3; 17 12.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26101088..26138688, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25882114..25919714, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 26 Neighboring gene WAP, FS, Ig, KU, and NTR-containing protein 1 Neighboring gene cytochrome c oxidase subunit 7C, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:26056925-26057108 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene NHL repeat containing 4 Neighboring gene RIKEN cDNA gene D630044L22 gene Neighboring gene proline rich 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-40C
    Names
    RAR (RAS like GTPASE) like
    SOCS box containing protein RAR3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139154.2NP_631893.1  ras-related protein Rab-40C

      See identical proteins and their annotated locations for NP_631893.1

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Consensus CDS
      CCDS28537.1
      UniProtKB/Swiss-Prot
      Q8VHQ4
      UniProtKB/TrEMBL
      E9PXR4, Q0PD11
      Related
      ENSMUSP00000026826.8, ENSMUST00000026826.14
      Conserved Domains (2) summary
      cd04121
      Location:9281
      Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c
      cd03742
      Location:187229
      SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26101088..26138688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)