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    Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta [ Mus musculus (house mouse) ]

    Gene ID: 207565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Camkk2provided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase kinase 2, betaprovided by MGI
    Primary source
    MGI:MGI:2444812
    See related
    Ensembl:ENSMUSG00000029471 AllianceGenome:MGI:2444812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0787; 6330570N16Rik
    Summary
    Predicted to enable calcium ion binding activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in CAMKK-AMPK signaling cascade; positive regulation of protein phosphorylation; and protein autophosphorylation. Predicted to be located in cytosol. Is expressed in central nervous system; dorsal root ganglion; neural retina; testis; and trigeminal nerve. Orthologous to human CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 29.2), cerebellum adult (RPKM 25.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Camkk2 in Genome Data Viewer
    Location:
    5 F; 5 62.55 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122856064..122918295, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122718380..122779522, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 7 Neighboring gene microRNA 8115 Neighboring gene STARR-seq mESC enhancer starr_14295 Neighboring gene predicted gene 10064 Neighboring gene purinergic receptor P2X, ligand-gated ion channel 4 Neighboring gene STARR-positive B cell enhancer ABC_E3614 Neighboring gene STARR-seq mESC enhancer starr_14298 Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E10348 Neighboring gene STARR-positive B cell enhancer ABC_E1307 Neighboring gene STARR-positive B cell enhancer ABC_E2762 Neighboring gene predicted gene, 33044

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Conditional loss of CaMKK2 in Osterix-positive osteoprogenitors enhances osteoblast function in a sex-divergent manner. Mattingly BT, et al. Bone, 2024 Jul. PMID 38703937,
    2. The Ca2+/calmodulin-dependent protein kinase kinase, CaMKK2, inhibits preadipocyte differentiation. Lin F, et al. Endocrinology, 2011 Oct. PMID 21862616, Free PMC Article
    3. Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. Anderson KA, et al. Mol Endocrinol, 2012 Feb. PMID 22240810, Free PMC Article
    4. Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. Cary RL, et al. J Bone Miner Res, 2013 Jul. PMID 23408651, Free PMC Article
    5. Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-β leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice. Watanabe S, et al. PLoS One, 2014. PMID 25255457, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKbeta in diabetic kidney disease.
      Title: Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKβ in diabetic kidney disease.
    2. Conditional loss of CaMKK2 in Osterix-positive osteoprogenitors enhances osteoblast function in a sex-divergent manner.
      Title: Conditional loss of CaMKK2 in Osterix-positive osteoprogenitors enhances osteoblast function in a sex-divergent manner.
    3. Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
      Title: Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
    4. Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin.
      Title: Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin.
    5. CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle.
      Title: CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle.
    6. Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells.
      Title: Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells.
    7. CaMKK2 Knockout Bone Marrow Cells Collected/Processed in Low Oxygen (Physioxia) Suggests CaMKK2 as a Hematopoietic Stem to Progenitor Differentiation Fate Determinant.
      Title: CaMKK2 Knockout Bone Marrow Cells Collected/Processed in Low Oxygen (Physioxia) Suggests CaMKK2 as a Hematopoietic Stem to Progenitor Differentiation Fate Determinant.
    8. Abeta42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.
      Title: Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.
    9. Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.
      Title: Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.
    10. Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer.
      Title: Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (7)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAMKK-AMPK signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAMKK-AMPK signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CAMKK-AMPK signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase kinase 2
    Names
    caM-KK 2
    caM-KK beta
    caM-kinase kinase 2
    caM-kinase kinase beta
    caMKK 2
    caMKK beta
    calcium/calmodulin-dependent protein kinase kinase beta
    NP_001186605.1
    NP_663333.1
    XP_006530293.1
    XP_006530294.1
    XP_006530295.1
    XP_006530296.1
    XP_006530297.1
    XP_006530298.1
    XP_006530299.1
    XP_017176252.1
    XP_030110166.1
    XP_030110167.1
    XP_036020841.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199676.1 → NP_001186605.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_001186605.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC115728, AK031399, AK032070, AK042935, AW045178
      Consensus CDS
      CCDS80395.1
      UniProtKB/Swiss-Prot
      Q80TS0, Q8BXM8, Q8C078, Q8C0G3, Q8CH42, Q8QZT7
      Related
      ENSMUSP00000107297.5, ENSMUST00000111668.8
      Conserved Domains (1) summary
      cl21453
      Location:162 → 447
      PKc_like; Protein Kinases, catalytic domain

    2. NM_145358.2 → NP_663333.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_663333.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which shifts the reading frame, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC115728, AK031399, AK042935, AW045178, CK625345
      Consensus CDS
      CCDS19655.1
      UniProtKB/Swiss-Prot
      Q8C078
      Related
      ENSMUSP00000143732.2, ENSMUST00000200109.5
      Conserved Domains (2) summary
      smart00220
      Location:165 → 446
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:162 → 447
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122856064..122918295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530234.5 → XP_006530297.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

      Conserved Domains (1) summary
      cl21453
      Location:162 → 447
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030254306.2 → XP_030110166.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006530235.5 → XP_006530298.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006530233.5 → XP_006530296.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain

    5. XM_017320763.3 → XP_017176252.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

      UniProtKB/Swiss-Prot
      Q80TS0, Q8BXM8, Q8C078, Q8C0G3, Q8CH42, Q8QZT7
      Conserved Domains (1) summary
      cl21453
      Location:162 → 447
      PKc_like; Protein Kinases, catalytic domain

    6. XM_030254307.1 → XP_030110167.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:1 → 255
      PKc_like; Protein Kinases, catalytic domain

    7. XM_036164948.1 → XP_036020841.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10

      Conserved Domains (1) summary
      cl21453
      Location:1 → 255
      PKc_like; Protein Kinases, catalytic domain

    8. XM_006530230.5 → XP_006530293.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530293.1

      UniProtKB/Swiss-Prot
      Q8C078
      Conserved Domains (1) summary
      cl21453
      Location:162 → 447
      PKc_like; Protein Kinases, catalytic domain

    9. XM_006530231.5 → XP_006530294.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530294.1

      UniProtKB/Swiss-Prot
      Q8C078
      Conserved Domains (1) summary
      cl21453
      Location:162 → 447
      PKc_like; Protein Kinases, catalytic domain

    10. XM_006530236.5 → XP_006530299.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JET2
      Related
      ENSMUSP00000142896.2, ENSMUST00000198029.5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 255
      PKc_like; Protein Kinases, catalytic domain

    11. XM_006530232.5 → XP_006530295.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:162 → 442
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C078.2 GenPept UniProtKB/Swiss-Prot:Q8C078

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