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    Jmjd8 jumonji domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 72106, updated on 27-Nov-2024

    Summary

    Official Symbol
    Jmjd8provided by MGI
    Official Full Name
    jumonji domain containing 8provided by MGI
    Primary source
    MGI:MGI:1919356
    See related
    Ensembl:ENSMUSG00000025736 AllianceGenome:MGI:1919356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610003J06Rik
    Summary
    Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of sprouting angiogenesis; and regulation of pyruvate kinase activity. Predicted to be located in endoplasmic reticulum lumen and nucleus. Predicted to be active in cytoplasm. Is expressed in brain; gonad; lung; metanephros; and submandibular gland. Orthologous to human JMJD8 (jumonji domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 71.8), kidney adult (RPKM 66.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Jmjd8 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26048017..26050817)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25829043..25831843)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 16 Neighboring gene STARR-positive B cell enhancer ABC_E7500 Neighboring gene WD repeat domain 24 Neighboring gene STARR-positive B cell enhancer ABC_E3192 Neighboring gene microRNA 3082 Neighboring gene STIP1 homology and U-Box containing protein 1 Neighboring gene rhomboid like 1 Neighboring gene ras homolog family member T2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of pyruvate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of pyruvate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    jmjC domain-containing protein 8
    Names
    jumonji domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028101.5NP_082377.3  jmjC domain-containing protein 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AK155810, BE982271
      Consensus CDS
      CCDS28532.2
      UniProtKB/Swiss-Prot
      A0A3B2W707, Q3TA59, Q3U1Q1, Q91XD9, Q9D0L5
      UniProtKB/TrEMBL
      A0A9L6H220
      Related
      ENSMUSP00000026832.8, ENSMUST00000026832.14
      Conserved Domains (1) summary
      cl21464
      Location:59253
      cupin_like; Conserved domain found in cupin and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26048017..26050817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)