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    Antkmt adenine nucleotide translocase lysine methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 214917, updated on 9-Dec-2024

    Summary

    Official Symbol
    Antkmtprovided by MGI
    Official Full Name
    adenine nucleotide translocase lysine methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2384888
    See related
    Ensembl:ENSMUSG00000057411 AllianceGenome:MGI:2384888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ANT-KMT; Fam173a
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation and regulation of mitochondrial ATP synthesis coupled proton transport. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human ANTKMT (adenine nucleotide translocase lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 50.0), colon adult (RPKM 46.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Antkmt in Genome Data Viewer
    Location:
    17 A3.3; 17 12.89 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26009474..26011761, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25790500..25792787, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene F-box and leucine-rich repeat protein 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

    Markers

    Clone Names

    • MGC6974

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-lysine trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine trimethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrial ATP synthesis coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    adenine nucleotide translocase lysine N-methyltransferase
    Names
    family with sequence similarity 173, member A
    protein FAM173A
    protein N-lysine methyltransferase FAM173A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285982.1NP_001272911.1  adenine nucleotide translocase lysine N-methyltransferase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC134908
      Consensus CDS
      CCDS89025.1
      UniProtKB/TrEMBL
      Q91VW0
      Related
      ENSMUSP00000158301.2, ENSMUST00000236683.2
    2. NM_001357989.1NP_001344918.1  adenine nucleotide translocase lysine N-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134908, AI850632
      Consensus CDS
      CCDS89025.1
      UniProtKB/TrEMBL
      Q91VW0
    3. NM_145410.4NP_663385.2  adenine nucleotide translocase lysine N-methyltransferase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC134908, AK162337, BB855744
      Consensus CDS
      CCDS28528.1
      UniProtKB/Swiss-Prot
      Q501J2
      Related
      ENSMUSP00000072518.8, ENSMUST00000072735.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26009474..26011761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)