Map2k7 mitogen-activated protein kinase kinase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map2k7provided by MGI
Official Full Name: mitogen-activated protein kinase kinase 7provided by MGI
Primary source: MGI:MGI:1346871
See related: Ensembl:ENSMUSG00000002948 AllianceGenome:MGI:1346871
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mek7; Mkk7; sek2; Jnkk2; MEK 7; JNKK 2; Mapkk7; Prkmk7; MAPKK 7; 5930412N11Rik
Summary: Enables magnesium ion binding activity; protein kinase activity; and protein phosphatase binding activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of MAPK cascade. Acts upstream of or within regulation of motor neuron apoptotic process and response to wounding. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; lung; musculoskeletal system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 34.8), adrenal adult (RPKM 26.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 1.99 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (4288740..4297897)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (4238740..4247897)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.
Title: Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.
The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.
Title: The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.
Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells.
Title: Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells.
Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.
Title: Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.
MKK7 deficiency in mature neurons impairs parental behavior in mice.
Title: MKK7 deficiency in mature neurons impairs parental behavior in mice.
Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia.
Title: Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia.
These results suggest that MKK4 and MKK7 may serve redundant and unique roles in molecular signaling important for retinal development and injury response following axonal insult.
Title: Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.
we generated neuron-specific Mkk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system. MKK7 cKO mice displayed impaired circadian behavioral rhythms and decreased locomotor activity. MKK7 cKO mice at 8 months showed motor dysfunctions such as weakness of hind-limb and gait abnormality in an age-dependent manner.
Title: Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.
SENP3 potentiates lipopolysaccharide-induced TLR4 signaling via deSUMOylation of MKK7 leading to enhancement in JNK phosphorylation and the downstream events
Title: DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
High Map2k7 expression is associated with T-cell acute lymphoblastic leukemia.
Title: Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235822

NoName (e-PCR)
- UniSTS:235825

PMC355836P1 (e-PCR)
- UniSTS:273256

C87354 (e-PCR)
- UniSTS:179691

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IEA Inferred from Electronic Annotation more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 7

Names: JNK kinase 2; JNK-activating kinase 2; MAP kinase kinase 7; MAPK/ERK kinase 7; c-Jun N-terminal kinase kinase 2; protein kinase, mitogen activated, kinase 7

NP_001036022.1

EC 2.7.12.2

NP_001157644.1

EC 2.7.12.2

NP_001278706.1

EC 2.7.12.2

NP_001278707.1

EC 2.7.12.2

NP_001278712.1

EC 2.7.12.2

NP_036074.2

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042557.2 → NP_001036022.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 1

See identical proteins and their annotated locations for NP_001036022.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AB005654, BB842920

Consensus CDS

CCDS40208.1

UniProtKB/Swiss-Prot

O35406, O35720, O35871, O35872, O54780, O70242, O70243, Q8BSP1, Q8CE90, Q9QWG6, Q9R1Z3, Q9R1Z4, Q9R1Z5, Q9R1Z6

Related

ENSMUSP00000003027.8, ENSMUST00000003027.14

Conserved Domains (2) summary

smart00220
Location:137 → 396

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:120 → 416

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001164172.1 → NP_001157644.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 3

See identical proteins and their annotated locations for NP_001157644.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) retains the last intron compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC123029, BB842920, BC070467

Consensus CDS

CCDS52474.1

UniProtKB/Swiss-Prot

O35406, O35720, O35871, O35872, O54780, O70242, O70243, Q8BSP1, Q8CE90, Q9QWG6, Q9R1Z3, Q9R1Z4, Q9R1Z5, Q9R1Z6

Related

ENSMUSP00000054512.5, ENSMUST00000062686.11

Conserved Domains (1) summary

cd06618
Location:120 → 416

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001291777.1 → NP_001278706.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 4

See identical proteins and their annotated locations for NP_001278706.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB005654, AK165184, BB842920

Consensus CDS

CCDS80852.1

UniProtKB/Swiss-Prot

Q8CE90

Related

ENSMUSP00000106627.2, ENSMUST00000110999.8

Conserved Domains (2) summary

smart00220
Location:121 → 380

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:104 → 400

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001291778.1 → NP_001278707.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 5

See identical proteins and their annotated locations for NP_001278707.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AB005654, AC123029

Consensus CDS

CCDS80853.1

UniProtKB/Swiss-Prot

Q8CE90

Related

ENSMUSP00000106623.2, ENSMUST00000110995.8

Conserved Domains (1) summary

cd06618
Location:31 → 327

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001291783.1 → NP_001278712.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 6

See identical proteins and their annotated locations for NP_001278712.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and retains the last intron compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC123029, AF060944, AK049267, BC070467

Consensus CDS

CCDS80854.1

UniProtKB/Swiss-Prot

Q8CE90

Related

ENSMUSP00000106622.2, ENSMUST00000110994.9

Conserved Domains (1) summary

cd06618
Location:31 → 327

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_011944.3 → NP_036074.2 dual specificity mitogen-activated protein kinase kinase 7 isoform 2

See identical proteins and their annotated locations for NP_036074.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and retains the last intron compared to variant 1. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC123029, AK165184, BB842920, CO044477

Consensus CDS

CCDS40209.1

UniProtKB/Swiss-Prot

Q8CE90

Related

ENSMUSP00000106626.3, ENSMUST00000110998.9

Conserved Domains (1) summary

cd06618
Location:104 → 400

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7