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    Arid2 AT-rich interaction domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 77044, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arid2provided by MGI
    Official Full Name
    AT-rich interaction domain 2provided by MGI
    Primary source
    MGI:MGI:1924294
    See related
    Ensembl:ENSMUSG00000033237 AllianceGenome:MGI:1924294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BAF200; zipzap/p200; 1700124K17Rik; 4432409D24Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within embryonic organ development; heart development; and homeostatic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of SWI/SNF complex and transcription regulator complex. Is expressed in central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.0), thymus adult (RPKM 22.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Arid2 in Genome Data Viewer
    Location:
    15 F1; 15 52.37 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (96185403..96303344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (96287522..96405463)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38469 Neighboring gene RIKEN cDNA 4833422M21 gene Neighboring gene RIKEN cDNA E330033B04 gene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:96114695-96114804 Neighboring gene STARR-seq mESC enhancer starr_39586 Neighboring gene STARR-seq mESC enhancer starr_39587 Neighboring gene SR-related CTD-associated factor 11 Neighboring gene STARR-positive B cell enhancer ABC_E9160 Neighboring gene STARR-positive B cell enhancer ABC_E8609 Neighboring gene predicted gene, 41408 Neighboring gene STARR-seq mESC enhancer starr_39591 Neighboring gene predicted gene, 41392

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within circulatory system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within coronary artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostatic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myoblast differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of SWI/SNF complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SWI/SNF superfamily-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SWI/SNF superfamily-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nuclear matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    AT-rich interactive domain-containing protein 2
    Names
    ARID domain-containing protein 2
    AT rich interactive domain 2 (ARID, RFX-like)
    AT rich interactive domain 2 (Arid-rfx like)
    BRG1-associated factor 200
    zinc finger protein with activation potential
    zipzap

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175251.4NP_780460.3  AT-rich interactive domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC133578, AK007269, AK077366, BU056807, CA749551, CK781204, CV559640
      Consensus CDS
      CCDS37185.2
      UniProtKB/Swiss-Prot
      E9Q7E2
      Related
      ENSMUSP00000093969.5, ENSMUST00000096250.5
      Conserved Domains (4) summary
      pfam01388
      Location:19101
      ARID; ARID/BRIGHT DNA binding domain
      pfam02257
      Location:521601
      RFX_DNA_binding; RFX DNA-binding domain
      cl26464
      Location:603910
      Atrophin-1; Atrophin-1 family
      cl26809
      Location:12781575
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      96185403..96303344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159626.1XP_036015519.1  AT-rich interactive domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      PTZ00395
      Location:11291426
      PTZ00395; Sec24-related protein; Provisional
      pfam02257
      Location:372452
      RFX_DNA_binding; RFX DNA-binding domain
      cl41773
      Location:5271003
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4