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    Metrn meteorin, glial cell differentiation regulator [ Mus musculus (house mouse) ]

    Gene ID: 70083, updated on 9-Dec-2024

    Summary

    Official Symbol
    Metrnprovided by MGI
    Official Full Name
    meteorin, glial cell differentiation regulatorprovided by MGI
    Primary source
    MGI:MGI:1917333
    See related
    Ensembl:ENSMUSG00000002274 AllianceGenome:MGI:1917333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hyrac; EyeLinc16; 1810034B16Rik
    Summary
    Predicted to enable hormone activity. Acts upstream of or within positive regulation of axonogenesis and radial glial cell differentiation. Located in extracellular space. Is expressed in several structures, including eye; genitourinary system; gut; nervous system; and spleen. Orthologous to human METRN (meteorin, glial cell differentiation regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 88.3), CNS E11.5 (RPKM 57.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Metrn in Genome Data Viewer
    Location:
    17 A3.3; 17 12.89 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26013545..26016019, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25794571..25797045, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene F-box and leucine-rich repeat protein 16 Neighboring gene STARR-positive B cell enhancer ABC_E7500 Neighboring gene WD repeat domain 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within radial glial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    meteorin
    Names
    hypoxia/reoxygenation regulatory factor in astrocytes

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133719.2NP_598480.1  meteorin precursor

      See identical proteins and their annotated locations for NP_598480.1

      Status: VALIDATED

      Source sequence(s)
      AK087402, BF472326
      Consensus CDS
      CCDS28529.1
      UniProtKB/Swiss-Prot
      Q45G31, Q6P6N6, Q8C1Q4, Q8CI64, Q922A8
      UniProtKB/TrEMBL
      A0A494B937, A2RSN4
      Related
      ENSMUSP00000127275.2, ENSMUST00000165838.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26013545..26016019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)