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    Wfikkn1 WAP, FS, Ig, KU, and NTR-containing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 215001, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wfikkn1provided by MGI
    Official Full Name
    WAP, FS, Ig, KU, and NTR-containing protein 1provided by MGI
    Primary source
    MGI:MGI:2670967
    See related
    Ensembl:ENSMUSG00000071192 AllianceGenome:MGI:2670967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gasp2; Wfikkn
    Summary
    Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Acts upstream of or within muscle cell development; roof of mouth development; and skeletal system development. Located in extracellular region. Is expressed in several structures, including adipose tissue; genitourinary system; lung; skeletal muscle; and spleen. Orthologous to human WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 1.5), stomach adult (RPKM 1.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wfikkn1 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.97 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26096602..26099832, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25877628..25880858, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10938 Neighboring gene nuclear encoded tRNA glycine 7 (anticodon CCC) Neighboring gene methyltransferase like 26 Neighboring gene Rab40C, member RAS oncogene family Neighboring gene cytochrome c oxidase subunit 7C, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:26056925-26057108 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene NHL repeat containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
    Names
    GASP-2
    growth and differentiation factor-associated serum protein 2
    mGASP-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100454.1NP_001093924.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_001093924.1

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Consensus CDS
      CCDS50038.1
      UniProtKB/Swiss-Prot
      Q8R0S6
      UniProtKB/TrEMBL
      A0A498WFR4
      Related
      ENSMUSP00000135083.3, ENSMUST00000176696.3
      Conserved Domains (7) summary
      cd05765
      Location:204284
      Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
      smart00131
      Location:361413
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00104
      Location:124161
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam07679
      Location:196284
      I-set; Immunoglobulin I-set domain
      pfam00095
      Location:3480
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      cl00101
      Location:311356
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      cl02512
      Location:431541
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26096602..26099832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)