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    Ube2j2 ubiquitin-conjugating enzyme E2J 2 [ Mus musculus (house mouse) ]

    Gene ID: 140499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ube2j2provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2J 2provided by MGI
    Primary source
    MGI:MGI:2153608
    See related
    Ensembl:ENSMUSG00000023286 AllianceGenome:MGI:2153608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubc6; Ubc6p; NCUBE-2; 1200007B18Rik; 2400008G19Rik; 5730472G04Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway; protein K6-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 19.1), colon adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2j2 in Genome Data Viewer
    Location:
    4 E2; 4 87.66 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156028270..156044061)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155943813..155959604)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9250 Neighboring gene STARR-seq mESC enhancer starr_12276 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel, nonvoltage-gated 1, delta Neighboring gene STARR-positive B cell enhancer ABC_E10298 Neighboring gene STARR-seq mESC enhancer starr_12277 Neighboring gene C1q and tumor necrosis factor related 12 Neighboring gene STARR-seq mESC enhancer starr_12278 Neighboring gene predicted gene, 42365 Neighboring gene STARR-seq mESC enhancer starr_12279 Neighboring gene UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. Wang X, et al. J Cell Biol, 2009 Nov 30. PMID 19951915, Free PMC Article
    2. A role for mammalian Ubc6 homologues in ER-associated protein degradation. Lenk U, et al. J Cell Sci, 2002 Jul 15. PMID 12082160
    3. TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. Wu CJ, et al. EMBO J, 2005 May 18. PMID 15861135, Free PMC Article
    4. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). Tiwari S, et al. J Biol Chem, 2001 May 11. PMID 11278356
    5. A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate. Polge C, et al. J Cachexia Sarcopenia Muscle, 2018 Feb. PMID 29271608, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 J2
    Names
    Ubc6p homolog
    non-canonical ubiquitin-conjugating enzyme 2
    ubiquitin conjugating enzyme 6
    ubiquitin-conjugating enzyme E2, J2 homolog
    NP_001034246.1
    NP_001034247.1
    NP_001034248.1
    NP_001271241.1
    NP_001271243.1
    NP_067377.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039157.2 → NP_001034246.1  ubiquitin-conjugating enzyme E2 J2 isoform a

      See identical proteins and their annotated locations for NP_001034246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (a).
      Source sequence(s)
      AK004626, AK010302, AL627204, BC065779
      Consensus CDS
      CCDS19050.1
      UniProtKB/TrEMBL
      B1ASK8
      Related
      ENSMUSP00000101208.3, ENSMUST00000105583.9
      Conserved Domains (1) summary
      cd00195
      Location:26 → 139
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001039158.2 → NP_001034247.1  ubiquitin-conjugating enzyme E2 J2 isoform b

      See identical proteins and their annotated locations for NP_001034247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform b, which has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK004626, AL627204, BC065779
      Consensus CDS
      CCDS19051.1
      UniProtKB/Swiss-Prot
      Q6P073, Q8C6A1, Q91Y64, Q9CWY5, Q9DC18, Q9QX58
      Related
      ENSMUSP00000127712.2, ENSMUST00000166489.8
      Conserved Domains (1) summary
      cd00195
      Location:14 → 127
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_001039159.2 → NP_001034248.1  ubiquitin-conjugating enzyme E2 J2 isoform b

      See identical proteins and their annotated locations for NP_001034248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform b, which has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK004626, AL627204, BC065779
      Consensus CDS
      CCDS19051.1
      UniProtKB/Swiss-Prot
      Q6P073, Q8C6A1, Q91Y64, Q9CWY5, Q9DC18, Q9QX58
      Related
      ENSMUSP00000099464.2, ENSMUST00000103175.8
      Conserved Domains (1) summary
      cd00195
      Location:14 → 127
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_001284312.1 → NP_001271241.1  ubiquitin-conjugating enzyme E2 J2 isoform a

      See identical proteins and their annotated locations for NP_001271241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (a).
      Source sequence(s)
      AL627204, BC065779
      Consensus CDS
      CCDS19050.1
      UniProtKB/TrEMBL
      B1ASK8
      Related
      ENSMUSP00000101207.2, ENSMUST00000105582.8
      Conserved Domains (1) summary
      cd00195
      Location:26 → 139
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. NM_001284314.1 → NP_001271243.1  ubiquitin-conjugating enzyme E2 J2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, 5' and 3' coding regions and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AK004626, AL627204, AW826087, BC065779
      Consensus CDS
      CCDS71536.1
      UniProtKB/TrEMBL
      B0QZM1
      Related
      ENSMUSP00000112785.2, ENSMUST00000118192.8
      Conserved Domains (1) summary
      cd00195
      Location:14 → 127
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    6. NM_021402.6 → NP_067377.4  ubiquitin-conjugating enzyme E2 J2 isoform a

      See identical proteins and their annotated locations for NP_067377.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 5 encode the same isoform (a).
      Source sequence(s)
      AK004626, AK010302, AL627204, BC065779
      Consensus CDS
      CCDS19050.1
      UniProtKB/TrEMBL
      B1ASK8
      Related
      ENSMUSP00000024056.4, ENSMUST00000024056.10
      Conserved Domains (1) summary
      cd00195
      Location:26 → 139
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156028270..156044061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P073.1 GenPept UniProtKB/Swiss-Prot:Q6P073

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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