Tac1 tachykinin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tac1provided by MGI
Official Full Name: tachykinin 1provided by MGI
Primary source: MGI:MGI:98474
See related: Ensembl:ENSMUSG00000061762 AllianceGenome:MGI:98474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SP; NK1; NK-1; Nkna; PPTA; PPT-A; 4930528L02Rik
Summary: Predicted to enable neurokinin receptor binding activity and receptor ligand activity. Acts upstream of or within several processes, including cellular response to nerve growth factor stimulus; response to pain; and sensory perception of pain. Located in axon; extracellular region; and neuronal cell body. Is expressed in several structures, including alimentary system; integumental system; limb; nervous system; and sensory organ. Orthologous to human TAC1 (tachykinin precursor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 16.9), whole brain E14.5 (RPKM 7.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 3.31 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (7555061..7562978)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (7555061..7562978)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Substance P in the medial amygdala regulates aggressive behaviors in male mice.
Title: Substance P in the medial amygdala regulates aggressive behaviors in male mice.
Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.
Title: Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.
Substance P aggravates ligature-induced periodontitis in mice.
Title: Substance P aggravates ligature-induced periodontitis in mice.
Activation of Parabrachial Tachykinin 1 Neurons Counteracts Some Behaviors Mediated by Parabrachial Calcitonin Gene-related Peptide Neurons.
Title: Activation of Parabrachial Tachykinin 1 Neurons Counteracts Some Behaviors Mediated by Parabrachial Calcitonin Gene-related Peptide Neurons.
Substance P-induced lung inflammation in mice is mast cell dependent.
Title: Substance P-induced lung inflammation in mice is mast cell dependent.
CD4(+)/IL4(+) lymphocytes of the lamina propria and substance P promote colonic protection during acute stress.
Title: CD4(+)/IL‑4(+) lymphocytes of the lamina propria and substance P promote colonic protection during acute stress.
Inhibition of angiotensin converting enzyme induces mechanical allodynia through increasing substance P expression in mice.
Title: Inhibition of angiotensin converting enzyme induces mechanical allodynia through increasing substance P expression in mice.
Substance P Mediates Estrogen Modulation Proinflammatory Cytokines Release in Intervertebral Disc.
Title: Substance P Mediates Estrogen Modulation Proinflammatory Cytokines Release in Intervertebral Disc.
Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
Title: Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits.
Title: Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits.

Submit: New GeneRIF Correction See all GeneRIFs (118)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491280

Tac1 (e-PCR), detects polymorphism
- UniSTS:480301

D17584 (e-PCR)
- UniSTS:207923

Tac1 (e-PCR), detects polymorphism
- UniSTS:507267

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuromedin K receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables substance K receptor binding	ISO Inferred from Sequence Orthology more info
enables substance P receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables substance P receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to yeast	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tachykinin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protachykinin-1

Names: neurokinin 1; neurokinin A; preprotachykinin A; substance P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311060.2 → NP_001297989.1 protachykinin-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001297989.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AI835507, AI837972, CJ059943, CX238160

Consensus CDS

CCDS80486.1

UniProtKB/TrEMBL

B7ZMQ2

Related

ENSMUSP00000138818.2, ENSMUST00000184986.2
NM_009311.3 → NP_033337.1 protachykinin-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_033337.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC132117

Consensus CDS

CCDS19906.1

UniProtKB/Swiss-Prot

P41539, Q00073

UniProtKB/TrEMBL

Q149W7

Related

ENSMUSP00000139347.2, ENSMUST00000185187.8