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    Tmem132e transmembrane protein 132E [ Mus musculus (house mouse) ]

    Gene ID: 270893, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem132eprovided by MGI
    Official Full Name
    transmembrane protein 132Eprovided by MGI
    Primary source
    MGI:MGI:2685490
    See related
    Ensembl:ENSMUSG00000020701 AllianceGenome:MGI:2685490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm644
    Summary
    Predicted to be involved in posterior lateral line neuromast hair cell development. Located in cell body. Is expressed in nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to human TMEM132E (transmembrane protein 132E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 5.4), cerebellum adult (RPKM 3.2) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmem132e in Genome Data Viewer
    Location:
    11 C; 11 50.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82279281..82338447)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82388852..82447621)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 1 Neighboring gene STARR-seq mESC enhancer starr_30173 Neighboring gene predicted gene, 38577 Neighboring gene predicted gene, 53691 Neighboring gene predicted gene, 24612

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304439.2NP_001291368.1  transmembrane protein 132E precursor

      Status: VALIDATED

      Source sequence(s)
      AL645797
      Consensus CDS
      CCDS25144.2
      UniProtKB/Swiss-Prot
      A0A0A0MQ93, B7ZN59, Q5SUX0, Q6IEE6
      UniProtKB/TrEMBL
      A0A494B870
      Related
      ENSMUSP00000052484.5, ENSMUST00000054245.8
      Conserved Domains (3) summary
      pfam15705
      Location:45175
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:877942
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:451796
      TMEM132; Transmembrane protein family 132

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82279281..82338447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533452.5XP_006533515.1  transmembrane protein 132E isoform X2

      Conserved Domains (2) summary
      pfam15705
      Location:45176
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam16070
      Location:451797
      TMEM132; Transmembrane protein family 132
    2. XM_036156736.1XP_036012629.1  transmembrane protein 132E isoform X3

      Conserved Domains (2) summary
      pfam15706
      Location:581646
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:155501
      TMEM132; Transmembrane protein family 132
    3. XM_006533449.5XP_006533512.1  transmembrane protein 132E isoform X1

      UniProtKB/TrEMBL
      A0A494B870
      Conserved Domains (3) summary
      pfam15705
      Location:47178
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:879944
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:453799
      TMEM132; Transmembrane protein family 132

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023438.2: Suppressed sequence

      Description
      NM_023438.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.