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    Dlx6os1 distal-less homeobox 6, opposite strand 1 [ Mus musculus (house mouse) ]

    Gene ID: 320038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dlx6os1provided by MGI
    Official Full Name
    distal-less homeobox 6, opposite strand 1provided by MGI
    Primary source
    MGI:MGI:2443217
    See related
    AllianceGenome:MGI:2443217
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evf1; Evf2; Evf-1; Evf-2; Shhrs; Evf1/2; Dlx6as1; A230055N17Rik
    Summary
    Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in branchial arch; forebrain; and reproductive system. Orthologous to human DLX6-AS1 (DLX6 antisense RNA 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 8.1), frontal lobe adult (RPKM 7.4) and 5 other tissues See more
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    Genomic context

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    See Dlx6os1 in Genome Data Viewer
    Location:
    6 A1; 6 2.68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (6820543..6871627, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (6820543..6871627, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52890 Neighboring gene predicted gene, 34871 Neighboring gene STARR-seq mESC enhancer starr_15087 Neighboring gene distal-less homeobox 6, opposite strand 2 Neighboring gene distal-less homeobox 6 Neighboring gene predicted gene, 53323 Neighboring gene distal-less homeobox 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Liu L, et al. Behav Brain Res, 2022 Aug 5. PMID 35550840
    2. Preosteoblast-enriched lnc-Evf2 facilitates osteogenic differentiation by targeting Notch. Zhang Z, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Feb 4. PMID 33377486
    3. Developmental regulation of EVF-1, a novel non-coding RNA transcribed upstream of the mouse Dlx6 gene. Kohtz JD, et al. Gene Expr Patterns, 2004 Jul. PMID 15183307
    4. LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2. Chen YX, et al. Kidney Blood Press Res, 2022. PMID 35038705
    5. cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1. Zheng W, et al. Metabolism, 2022 Apr. PMID 35093327

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA DLX6-AS1 is the key mediator of glomerular podocyte injury and albuminuria in diabetic nephropathy by targeting the miR-346/GSK-3beta signaling pathway.
      Title: Long non-coding RNA DLX6-AS1 is the key mediator of glomerular podocyte injury and albuminuria in diabetic nephropathy by targeting the miR-346/GSK-3β signaling pathway.
    2. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis.
      Title: LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis.
    3. LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2.
      Title: LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2.
    4. Preosteoblast-enriched lnc-Evf2 facilitates osteogenic differentiation by targeting Notch.
      Title: Preosteoblast-enriched lnc-Evf2 facilitates osteogenic differentiation by targeting Notch.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Other Names

    • Dlx6 antisense RNA 1
    • Dlx6 opposite strand RNA 1
    • Dlx6 opposite strand transcript 1
    • sonic hedgehog regulated sequence

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015388.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK032537, BE989474

    2. NR_155495.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122240, AK044034, BE989474, BY126923

    3. NR_155496.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122240

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      6820543..6871627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials