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    Fbxl16 F-box and leucine-rich repeat protein 16 [ Mus musculus (house mouse) ]

    Gene ID: 214931, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl16provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 16provided by MGI
    Primary source
    MGI:MGI:2448488
    See related
    Ensembl:ENSMUSG00000025738 AllianceGenome:MGI:2448488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scirr1
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adrenal gland; gut; male reproductive gland or organ; and nervous system. Orthologous to human FBXL16 (F-box and leucine rich repeat protein 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 168.0), frontal lobe adult (RPKM 157.2) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fbxl16 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26027435..26040236)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25808461..25821262)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene STARR-positive B cell enhancer ABC_E7500 Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene microRNA 3082 Neighboring gene STIP1 homology and U-Box containing protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164225.2NP_001157697.1  F-box/LRR-repeat protein 16 isoform 1

      See identical proteins and their annotated locations for NP_001157697.1

      Status: VALIDATED

      Source sequence(s)
      AC134908, AC159277
      Consensus CDS
      CCDS50036.1
      UniProtKB/Swiss-Prot
      A2RT62
      UniProtKB/TrEMBL
      B2RPY3
      Related
      ENSMUSP00000048562.8, ENSMUST00000045692.9
      Conserved Domains (2) summary
      cd09293
      Location:201413
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:220243
      LRR_AMN1; leucine-rich repeat [structural motif]
    2. NM_001379393.1NP_001366322.1  F-box/LRR-repeat protein 16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134908, AC159277
      UniProtKB/Swiss-Prot
      A2RT62
      UniProtKB/TrEMBL
      B2RPY3
      Conserved Domains (2) summary
      cd09293
      Location:201413
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:220243
      LRR_AMN1; leucine-rich repeat [structural motif]
    3. NM_001379394.1NP_001366323.1  F-box/LRR-repeat protein 16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134908, AC159277
      Conserved Domains (3) summary
      cd09293
      Location:297509
      AMN1; Antagonist of mitotic exit network protein 1
      PHA03247
      Location:31193
      PHA03247; large tegument protein UL36; Provisional
      sd00034
      Location:316339
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26027435..26040236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)