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    Rad51d RAD51 paralog D [ Mus musculus (house mouse) ]

    Gene ID: 19364, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rad51dprovided by MGI
    Official Full Name
    RAD51 paralog Dprovided by MGI
    Primary source
    MGI:MGI:1261809
    See related
    Ensembl:ENSMUSG00000018841 AllianceGenome:MGI:1261809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRAD; R51H3; Rad51l3; Trad-d5
    Summary
    This gene belongs to the Rad51 gene family whose products play a major role in homologous recombination and DNA repair. The encoded protein interacts with other proteins of this family, including Rad51b, Rad51c and Xrcc2, and plays an essential role in both DNA repair and telomere maintenance. In humans, germline mutations in this gene may be associated with predisposition to ovarian cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 3.8), bladder adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rad51d in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82762786..82781571, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82871960..82890624, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11423 Neighboring gene ligase III, DNA, ATP-dependent Neighboring gene ring finger and FYVE like domain containing protein Neighboring gene STARR-seq mESC enhancer starr_30179 Neighboring gene STARR-positive B cell enhancer ABC_E8433 Neighboring gene fibronectin type III domain containing 8 Neighboring gene notchless homolog 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC61386, DKFZp586D0122

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent DNA damage sensor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent activity, acting on DNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables four-way junction DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA strand invasion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA strand invasion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomere maintenance via recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    located_in replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    DNA repair protein RAD51 homolog 4
    Names
    RAD51 homolog D
    RAD51-like 3
    TRAD/RAD51L3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277938.1NP_001264867.1  DNA repair protein RAD51 homolog 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Rad51d-7b or Trad-d2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL603745, AL646089
      UniProtKB/TrEMBL
      Q9EP87
      Conserved Domains (2) summary
      TIGR02236
      Location:10300
      recomb_radA; DNA repair and recombination protein RadA
      cd01123
      Location:82313
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    2. NM_001277939.1NP_001264868.1  DNA repair protein RAD51 homolog 4 isoform 3

      See identical proteins and their annotated locations for NP_001264868.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as Rad51d-delta10) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL603745, AL646089
      UniProtKB/TrEMBL
      B5LBC4, Q9EQS6
      Conserved Domains (2) summary
      smart00382
      Location:99266
      AAA; ATPases associated with a variety of cellular activities
      cd01123
      Location:82302
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    3. NM_001277941.1NP_001264870.1  DNA repair protein RAD51 homolog 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as Rad51d-delta5 or Trad-d6) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
      Source sequence(s)
      AL603745, AL646089
      Consensus CDS
      CCDS70267.1
      UniProtKB/TrEMBL
      B1ARD4, Q9EPC0
      Related
      ENSMUSP00000090520.7, ENSMUST00000092844.13
      Conserved Domains (2) summary
      TIGR02236
      Location:10260
      recomb_radA; DNA repair and recombination protein RadA
      cl21455
      Location:82273
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. NM_001277942.1NP_001264871.1  DNA repair protein RAD51 homolog 4 isoform 5

      See identical proteins and their annotated locations for NP_001264871.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as Rad51d-delta7,8 or Trad-d3) lacks two alternate exons resulting in the loss of an in-frame segment in the 3' coding region compared to variant 1. It encodes isoform 5 which is shorter than isoform 1.
      Source sequence(s)
      AL603745, AL646089
      Consensus CDS
      CCDS70268.1
      UniProtKB/TrEMBL
      Q9EP85, Q9EP87
      Related
      ENSMUSP00000021033.10, ENSMUST00000021033.16
      Conserved Domains (2) summary
      cl21455
      Location:82264
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23768
      Location:2692
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    5. NM_011235.4NP_035365.1  DNA repair protein RAD51 homolog 4 isoform 1

      See identical proteins and their annotated locations for NP_035365.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as Rad51d-FL) encodes the longest isoform (1).
      Source sequence(s)
      AK147759, AL646089, CJ141615
      Consensus CDS
      CCDS36250.1
      UniProtKB/Swiss-Prot
      O55230
      UniProtKB/TrEMBL
      Q3UGT8, Q9EQS6
      Related
      ENSMUSP00000018985.9, ENSMUST00000018985.15
      Conserved Domains (2) summary
      TIGR02236
      Location:10305
      recomb_radA; DNA repair and recombination protein RadA
      cd01123
      Location:82318
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

    RNA

    1. NR_102717.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as Rad51d-delta8 or Trad-d1) lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL603745, AL646089
    2. NR_102718.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as Rad51d-plus-int3 or Trad-d7) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL603745, AL646089
    3. NR_102719.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as Rad51d-delta3 or Trad-d4) lacks an alternate exon in the 5' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK036272, AL646089, CF746344, CJ141615
    4. NR_102720.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9, also known as Rad51d-delta3,7b or Trad-d5) lacks an alternate exon in the 5' region and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL603745, AL646089

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82762786..82781571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156455.1XP_036012348.1  DNA repair protein RAD51 homolog 4 isoform X1

      UniProtKB/TrEMBL
      Q9EQS6
      Conserved Domains (2) summary
      PRK09302
      Location:73126
      PRK09302; circadian clock protein KaiC; Reviewed
      cd19489
      Location:106311
      Rad51D; RAD51D recombinase