Nrg2 neuregulin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrg2provided by MGI
Official Full Name: neuregulin 2provided by MGI
Primary source: MGI:MGI:1098246
See related: Ensembl:ENSMUSG00000060275 AllianceGenome:MGI:1098246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Don1; NTAK
Summary: Enables receptor ligand activity. Involved in ERBB2-ERBB3 signaling pathway and ERBB4-ERBB4 signaling pathway. Is active in extracellular space. Is expressed in epidermis; heart; mammary gland primordium; nervous system; and surface ectoderm. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 3.5), ovary adult (RPKM 2.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.38 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (36147634..36332754, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (36014581..36197532, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteolytic Processing of Neuregulin 2.
Title: Proteolytic Processing of Neuregulin 2.
Findings reveal a novel role for NRG2 in the modulation of behaviors with relevance to psychiatric disorders.
Title: Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.
Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
Title: A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
in vivo NRG-2 activity differs substantially from that of NRG-1, and it is not essential for normal development
Title: Generation and characterization of neuregulin-2-deficient mice.
The distinct temporal, regional, and subcellular expression of NRG-2 in the developing brain suggests its unique and nonredundant role in neural function.
Title: Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons.
identify NRG2 as a factor capable of promoting subventricular zone proliferation, leading to the formation of new neurons in vivo
Title: The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nrg2 (e-PCR), detects polymorphism
- UniSTS:468011

D18Wox22 (e-PCR)
- UniSTS:518713

D18Mit120 (e-PCR), detects polymorphism
- UniSTS:128142

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ErbB-3 class receptor binding	ISO Inferred from Sequence Orthology more info
enables ErbB-4 class receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables epidermal growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERBB2-ERBB3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERBB4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB4 signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ERBB4-ERBB4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IPI Inferred from Physical Interaction more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pro-neuregulin-2, membrane-bound isoform

Names: pro-NRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167891.3 → NP_001161363.3 pro-neuregulin-2, membrane-bound isoform isoform 1

Status: VALIDATED

Source sequence(s)

AC127350, AC131191, AC141471

Consensus CDS

CCDS50255.1

UniProtKB/Swiss-Prot

P56974

UniProtKB/TrEMBL

D3YZR2

Related

ENSMUSP00000111378.2, ENSMUST00000115713.9

Conserved Domains (2) summary

pfam02158
Location:441 → 838

Neuregulin; Neuregulin family

cd05750
Location:248 → 339

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins
NM_001382420.1 → NP_001369349.1 pro-neuregulin-2, membrane-bound isoform isoform 2

Status: VALIDATED

Source sequence(s)

AC127350, AC131191, AC141471

UniProtKB/Swiss-Prot

P56974

Conserved Domains (3) summary

PHA02887
Location:354 → 397

PHA02887; EGF-like protein; Provisional

pfam02158
Location:443 → 840

Neuregulin; Neuregulin family

cd05750
Location:248 → 339

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

36147634..36332754 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250231.2 → XP_030106091.1 pro-neuregulin-2, membrane-bound isoform isoform X3

Conserved Domains (1) summary

pfam02158
Location:58 → 454

Neuregulin; Neuregulin family
XM_030250234.2 → XP_030106094.1 pro-neuregulin-2, membrane-bound isoform isoform X5

Conserved Domains (1) summary

pfam02158
Location:47 → 443

Neuregulin; Neuregulin family
XM_011246789.3 → XP_011245091.1 pro-neuregulin-2, membrane-bound isoform isoform X2

UniProtKB/TrEMBL

A0A6I8MWW5

Related

ENSMUSP00000159288.2, ENSMUST00000239409.2

Conserved Domains (3) summary

cd05750
Location:50 → 123

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA02887
Location:140 → 183

PHA02887; EGF-like protein; Provisional

pfam02158
Location:229 → 625

Neuregulin; Neuregulin family
XM_030250232.1 → XP_030106092.1 pro-neuregulin-2, membrane-bound isoform isoform X4

Conserved Domains (1) summary

pfam02158
Location:50 → 446

Neuregulin; Neuregulin family
XM_011246790.4 → XP_011245092.1 pro-neuregulin-2, membrane-bound isoform isoform X5

See identical proteins and their annotated locations for XP_011245092.1

Conserved Domains (1) summary

pfam02158
Location:47 → 443

Neuregulin; Neuregulin family
XM_006525462.5 → XP_006525525.1 pro-neuregulin-2, membrane-bound isoform isoform X1

UniProtKB/Swiss-Prot

P56974

Conserved Domains (3) summary

cd05750
Location:264 → 337

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA03099
Location:340 → 428

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam02158
Location:435 → 831

Neuregulin; Neuregulin family
XM_036160908.1 → XP_036016801.1 pro-neuregulin-2, membrane-bound isoform isoform X6

Conserved Domains (1) summary

pfam02158
Location:39 → 436

Neuregulin; Neuregulin family
XM_006525466.5 → XP_006525529.1 pro-neuregulin-2, membrane-bound isoform isoform X7

Conserved Domains (2) summary

cd05750
Location:264 → 337

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA02887
Location:354 → 394

PHA02887; EGF-like protein; Provisional
XM_011246792.4 → XP_011245094.1 pro-neuregulin-2, membrane-bound isoform isoform X8

Conserved Domains (2) summary

cd05750
Location:264 → 337

Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)

PHA02887
Location:354 → 394

PHA02887; EGF-like protein; Provisional