Cd200 CD200 molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd200provided by MGI
Official Full Name: CD200 moleculeprovided by MGI
Primary source: MGI:MGI:1196990
See related: Ensembl:ENSMUSG00000022661 AllianceGenome:MGI:1196990
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OX2; Mox2
Summary: Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion. Involved in negative regulation of cell population proliferation; negative regulation of macrophage activation; and negative regulation of neuroinflammatory response. Located in cell surface. Is active in postsynaptic density and presynaptic active zone. Is expressed in several structures, including bone; metanephros; nervous system; retina; and skin. Used to study autoimmune disease. Orthologous to human CD200 (CD200 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 82.1), whole brain E14.5 (RPKM 45.1) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 29.53 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (45202474..45229419, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (45382111..45409060, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brain endothelial CD200 signaling protects brain against ischemic damage.
Title: Brain endothelial CD200 signaling protects brain against ischemic damage.
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
Title: Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.
Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
Title: Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
Title: The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke.
Title: Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke.
CD200 -dependent and -independent immune-modulatory functions of neural stem cells.
Title: CD200 -dependent and -independent immune-modulatory functions of neural stem cells.
CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
Title: CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
Title: CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
The CD200 Regulates Inflammation in Mice Independently of TNF-alpha Production.
Title: The CD200 Regulates Inflammation in Mice Independently of TNF-α Production.
CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
Title: CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW558554 (e-PCR)
- UniSTS:209225

D16Mit84 (e-PCR), detects polymorphism
- UniSTS:127920

AF004023 (e-PCR)
- UniSTS:180921

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cell-cell adhesion mediator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding involved in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arginase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-glutamine gamma-glutamyltransferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: OX-2 membrane glycoprotein

Names: CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal antibody MRC OX-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358443.1 → NP_001345372.1 OX-2 membrane glycoprotein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC117686, AC117783

Conserved Domains (2) summary

pfam00047
Location:69 → 155

ig; Immunoglobulin domain

cl11960
Location:1 → 64

Ig; Immunoglobulin domain
NM_010818.3 → NP_034948.3 OX-2 membrane glycoprotein isoform 1 precursor

See identical proteins and their annotated locations for NP_034948.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC054759, CN665640

Consensus CDS

CCDS49860.1

UniProtKB/Swiss-Prot

O54816, O54901, Q9JHD5

UniProtKB/TrEMBL

Q80VX2

Related

ENSMUSP00000130518.2, ENSMUST00000163230.8

Conserved Domains (2) summary

cd05846
Location:44 → 140

Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins

pfam00047
Location:143 → 229

ig; Immunoglobulin domain

RNA

NR_189160.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117686, AC117783

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

45202474..45229419 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316890.3 → XP_017172379.1 OX-2 membrane glycoprotein isoform X1

Conserved Domains (1) summary

pfam00047
Location:47 → 133

ig; Immunoglobulin domain