Evl Ena-vasodilator stimulated phosphoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Evlprovided by MGI
Official Full Name: Ena-vasodilator stimulated phosphoproteinprovided by MGI
Primary source: MGI:MGI:1194884
See related: Ensembl:ENSMUSG00000021262 AllianceGenome:MGI:1194884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: b2b2600Clo
Summary: Enables SH3 domain binding activity and profilin binding activity. Involved in actin polymerization or depolymerization and positive regulation of actin filament polymerization. Acts upstream of or within cellular response to type II interferon. Located in focal adhesion; lamellipodium; and phagocytic vesicle. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and retina. Orthologous to human EVL (Enah/Vasp-like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 64.8), CNS E14 (RPKM 64.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 59.46 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (108520942..108654775)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (108554681..108688516)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
Title: EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
EVL selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependent manner.
Title: Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration.
Thus, unlike host proteins characterized in Shigella pathogenesis that promote bacterial spread, VASP and EVL function to limit it.
Title: Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery.
Altogether these observations demonstrate that ENA/VASP proteins are implicated in the establishment and maintenance of the axonal structure and that a change on their expression levels triggers neuronal degeneration.
Title: ENA/VASP downregulation triggers cell death by impairing axonal maintenance in hippocampal neurons.
Ena-vasp is required for endothelial barrier function in vivo.
Title: Ena/VASP is required for endothelial barrier function in vivo.
Ena/VASP proteins regulate cortical neuronal positioning.
Title: Ena/VASP proteins regulate cortical neuronal positioning.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI528774 (e-PCR)
- UniSTS:165845

BB390223 (e-PCR)
- UniSTS:208868

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables profilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables profilin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament-based movement	NAS Non-traceable Author Statement more info	PubMed
involved_in actin nucleation	NAS Non-traceable Author Statement more info	PubMed
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	NAS Non-traceable Author Statement more info	PubMed
involved_in barbed-end actin filament capping	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ena/VASP-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163394.1 → NP_001156866.1 ena/VASP-like protein isoform 1

See identical proteins and their annotated locations for NP_001156866.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC059810, BC096017

Consensus CDS

CCDS49167.1

UniProtKB/Swiss-Prot

P70429, Q9ERU8

UniProtKB/TrEMBL

Q6PB99

Related

ENSMUSP00000021689.7, ENSMUST00000021689.14

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:377 → 409

VASP_tetra; VASP tetramerisation domain
NM_001163395.1 → NP_001156867.1 ena/VASP-like protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region, uses a downstream start codon, and lacks an in-frame exon in the 3' coding region, compared to isoform 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AK134563, BC059810

Consensus CDS

CCDS49168.1

UniProtKB/TrEMBL

F8WJB9, Q6PB99

Related

ENSMUSP00000105480.3, ENSMUST00000109854.9

Conserved Domains (2) summary

cd01207
Location:11 → 119

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:362 → 394

VASP_tetra; VASP tetramerisation domain
NM_001163396.2 → NP_001156868.1 ena/VASP-like protein isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains alternate exons in the 5' coding region and uses a downstream start codon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AK134563, AK151633, BC059810

Consensus CDS

CCDS49169.1

UniProtKB/TrEMBL

E9PVP4, Q6PB99

Related

ENSMUSP00000133072.2, ENSMUST00000172409.2

Conserved Domains (2) summary

cd01207
Location:1 → 100

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:364 → 396

VASP_tetra; VASP tetramerization domain
NM_001422023.1 → NP_001408952.1 ena/VASP-like protein isoform 3

Status: VALIDATED

Source sequence(s)

AC137155, AC139568, AC152061

UniProtKB/TrEMBL

F8WJB9
NM_007965.3 → NP_031991.3 ena/VASP-like protein isoform 2

See identical proteins and their annotated locations for NP_031991.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

BC059810, BC096017

Consensus CDS

CCDS26161.1

UniProtKB/TrEMBL

Q6PB99

Related

ENSMUSP00000076916.6, ENSMUST00000077735.13

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:356 → 388

VASP_tetra; VASP tetramerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

108520942..108654775

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515470.3 → XP_006515533.1 ena/VASP-like protein isoform X1

UniProtKB/TrEMBL

Q6PB99

Conserved Domains (2) summary

cd01207
Location:11 → 119

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:383 → 415

VASP_tetra; VASP tetramerisation domain
XM_006515471.3 → XP_006515534.1 ena/VASP-like protein isoform X2

UniProtKB/TrEMBL

Q6PB99

Related

ENSMUSP00000152364.2, ENSMUST00000223109.2

Conserved Domains (2) summary

cd01207
Location:7 → 115

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:379 → 411

VASP_tetra; VASP tetramerisation domain