Scg2 secretogranin II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scg2provided by MGI
Official Full Name: secretogranin IIprovided by MGI
Primary source: MGI:MGI:103033
See related: Ensembl:ENSMUSG00000050711 AllianceGenome:MGI:103033
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chgc; SgII
Summary: Predicted to enable chemoattractant activity and cytokine activity. Involved in angiogenesis. Located in dense core granule. Is active in neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SCG2 (secretogranin II). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 52.5), cerebellum adult (RPKM 43.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 40.89 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (79412083..79417743, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (79434366..79440026, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SCG2 mediates blood-brain barrier dysfunction and schizophrenia-like behaviors after traumatic brain injury.
Title: SCG2 mediates blood-brain barrier dysfunction and schizophrenia-like behaviors after traumatic brain injury.
Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
Title: Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
Endogenous secretoneurin plasma levels are lower in newborn animals subjected to an excitotoxic insult than in healthy controls.
Title: Excitotoxicity Alters Endogenous Secretoneurin Plasma Levels, but Supplementation with Secretoneurin Does Not Protect Against Excitotoxic Neonatal Brain Injury.
Scg2 is a major secretory target of REST with a cell differentiation-enhancing activity in neural stem cells.
Title: REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II.
Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
Title: Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
Scg2 is a good candidate for the signal integrator required for activity-dependent plasticity such as associative learning and memory.
Title: The secretogranin II gene is a signal integrator of glutamate and dopamine inputs.
SgII binds directly to the secretory granule membrane and controls intracellular retention of proopiomelanocortin in AtT-20 cells.
Title: Multiple sorting systems for secretory granules ensure the regulated secretion of peptide hormones.
SgII mRNA levels were 10.5 fold upregulated in the left ventricle of animals with myocardial infarction and heart failure.
Title: Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties.
it was proven that ScgII cannot be categorized as an activity marker, but more likely plays a role in visual system plasticity by modulating a range of neurotransmitters and neuropeptides
Title: Monocular enucleation profoundly reduces secretogranin II expression in adult mouse visual cortex.
SN activates the protein kinase A (PKA) and cAMP-induced ERK signaling pathways in the LH-secreting mouse LbetaT2 pituitary cell line
Title: Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225312

Scg2 (e-PCR), detects polymorphism
- UniSTS:507207

Scg2 (e-PCR), detects polymorphism
- UniSTS:243343

X68837 (e-PCR)
- UniSTS:163255

Scg2 (e-PCR), detects polymorphism
- UniSTS:144372

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in induction of positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in dense core granule	IDA Inferred from Direct Assay more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretogranin-2

Names: chromogranin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310680.2 → NP_001297609.1 secretogranin-2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001297609.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC083887

Consensus CDS

CCDS78625.1

UniProtKB/TrEMBL

Q4W8U9

Related

ENSMUSP00000139740.2, ENSMUST00000185234.2

Conserved Domains (1) summary

pfam01271
Location:27 → 574

Granin; Granin (chromogranin or secretogranin)
NM_009129.3 → NP_033155.1 secretogranin-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_033155.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC083887

Consensus CDS

CCDS15089.1

UniProtKB/Swiss-Prot

Q03517, Q80Y79, Q9CW80

Related

ENSMUSP00000062556.5, ENSMUST00000049972.6

Conserved Domains (1) summary

pfam01271
Location:27 → 614

Granin; Granin (chromogranin or secretogranin)