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    Gabpb2 GA repeat binding protein, beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 213054, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gabpb2provided by MGI
    Official Full Name
    GA repeat binding protein, beta 2provided by MGI
    Primary source
    MGI:MGI:95612
    See related
    Ensembl:ENSMUSG00000038766 AllianceGenome:MGI:95612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gabpb2-1; 5830427M07; 1810015F01Rik; 9430006E19Rik; A430024B14Rik
    Summary
    Enables identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human GABPB2 (GA binding protein transcription factor subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.1), liver E14 (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gabpb2 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95089077..95125291, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95181766..95218110, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9169 Neighboring gene STARR-seq mESC enhancer starr_08369 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses. Jing X, et al. J Biol Chem, 2008 Sep 5. PMID 18628204, Free PMC Article
    2. Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells. Yu S, et al. Cell Stem Cell, 2012 Aug 3. PMID 22862946, Free PMC Article
    3. Neuregulin-1-stimulated phosphorylation of GABP in skeletal muscle cells. Fromm L, et al. Biochemistry, 2001 May 1. PMID 11318655
    4. Genes encoding the acetaminophen and selenium binding proteins map to mouse chromosome 3. Navarro CL, et al. Mamm Genome, 1996 Dec. PMID 8995767
    5. p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Mardaryev AN, et al. Development, 2014 Jan. PMID 24346698, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The findings identify the tetramer-forming GABPbeta2 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy.
      Title: Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.
    2. GABPbeta2 has a distinct role in restraining B cell expansion and humoral responses.
      Title: GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GA-binding protein subunit beta-2
    Names
    GA-binding protein beta-2-1
    GABP subunit beta-2
    GABP subunit beta-2-1
    GABPB-2
    NP_084161.1
    NP_766100.1
    XP_006501313.1
    XP_006501314.1
    XP_006501315.1
    XP_011238360.1
    XP_011238361.1
    XP_011238362.1
    XP_011238363.1
    XP_017175004.1
    XP_036018887.1
    XP_036018888.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029885.1 → NP_084161.1  GA-binding protein subunit beta-2

      See identical proteins and their annotated locations for NP_084161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC140190, AK141382, BP768545, CJ101339
      Consensus CDS
      CCDS17605.1
      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Related
      ENSMUSP00000121283.2, ENSMUST00000136139.8
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    2. NM_172512.2 → NP_766100.1  GA-binding protein subunit beta-2

      See identical proteins and their annotated locations for NP_766100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC140190, AK030849, BP768545, CJ101339
      Consensus CDS
      CCDS17605.1
      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Related
      ENSMUSP00000102827.2, ENSMUST00000107209.8
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95089077..95125291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501252.5 → XP_006501315.1  GA-binding protein subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006501315.1

      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    2. XM_006501251.5 → XP_006501314.1  GA-binding protein subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006501314.1

      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    3. XM_011240060.4 → XP_011238362.1  GA-binding protein subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_011238362.1

      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    4. XM_006501250.5 → XP_006501313.1  GA-binding protein subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006501313.1

      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    5. XM_036162994.1 → XP_036018887.1  GA-binding protein subunit beta-2 isoform X3

      Conserved Domains (2) summary
      COG0666
      Location:5 → 77
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:5 → 33
      ANK; ANK repeat [structural motif]

    6. XM_011240059.3 → XP_011238361.1  GA-binding protein subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_011238361.1

      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    7. XM_017319515.2 → XP_017175004.1  GA-binding protein subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      P81069
      Conserved Domains (4) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    8. XM_011240061.3 → XP_011238363.1  GA-binding protein subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_011238363.1

      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    9. XM_011240058.3 → XP_011238360.1  GA-binding protein subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_011238360.1

      UniProtKB/Swiss-Prot
      A7E218, P81069, Q8CDA6
      Conserved Domains (5) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam00769
      Location:298 → 359
      ERM; Ezrin/radixin/moesin family
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)

    10. XM_036162995.1 → XP_036018888.1  GA-binding protein subunit beta-2 isoform X4

      Conserved Domains (4) summary
      PHA02876
      Location:86 → 193
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42 → 130
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81069.2 GenPept UniProtKB/Swiss-Prot:P81069

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