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    Osbpl10 oxysterol binding protein-like 10 [ Mus musculus (house mouse) ]

    Gene ID: 74486, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Osbpl10provided by MGI
    Official Full Name
    oxysterol binding protein-like 10provided by MGI
    Primary source
    MGI:MGI:1921736
    See related
    Ensembl:ENSMUSG00000040875 AllianceGenome:MGI:1921736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OPR-10; ORP-10; 4933433D06Rik; C820004B04Rik
    Summary
    Predicted to enable cholesterol binding activity and phosphatidylserine binding activity. Predicted to be involved in lipid metabolic process and lipid transport. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in cytosol and membrane. Is expressed in several structures, including genitourinary system; heart; immune system; lung; and nervous system. Orthologous to human OSBPL10 (oxysterol binding protein like 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 17.5), small intestine adult (RPKM 2.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbpl10 in Genome Data Viewer
    Location:
    9 F3; 9 66.84 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114807531..115062341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114978485..115233273)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30448 Neighboring gene STARR-positive B cell enhancer ABC_E6808 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like Neighboring gene ribosomal protein S27, retrogene Neighboring gene STARR-seq mESC enhancer starr_25396 Neighboring gene STARR-seq mESC enhancer starr_25397 Neighboring gene STARR-positive B cell enhancer mm9_chr9:114953001-114953302 Neighboring gene predicted gene 4665 Neighboring gene predicted gene, 53513 Neighboring gene predicted gene, 26962 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) Neighboring gene stathmin 1, related sequence 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:115217576-115217877 Neighboring gene STARR-positive B cell enhancer ABC_E1395 Neighboring gene RIKEN cDNA 4930428G15 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
    2. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article
    3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 10
    Names
    OSBP-related protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148958.3 → NP_683761.2  oxysterol-binding protein-related protein 10

      Status: VALIDATED

      Source sequence(s)
      AC157586, AC160132, AC162179
      Consensus CDS
      CCDS40796.2
      UniProtKB/Swiss-Prot
      Q8R2T7, S4R1M9
      Related
      ENSMUSP00000138287.2, ENSMUST00000183104.8
      Conserved Domains (3) summary
      cd13291
      Location:79 → 185
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
      pfam01237
      Location:404 → 764
      Oxysterol_BP; Oxysterol-binding protein
      pfam10428
      Location:179 → 318
      SOG2; RAM signalling pathway protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      114807531..115062341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512377.4 → XP_006512440.1  oxysterol-binding protein-related protein 10 isoform X8

      Conserved Domains (1) summary
      cd13291
      Location:79 → 185
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain

    2. XM_006512371.4 → XP_006512434.1  oxysterol-binding protein-related protein 10 isoform X2

      Conserved Domains (2) summary
      cd13291
      Location:79 → 181
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
      pfam01237
      Location:340 → 700
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_011243052.4 → XP_011241354.1  oxysterol-binding protein-related protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A0R4J0F9
      Conserved Domains (2) summary
      pfam01237
      Location:310 → 670
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:2 → 91
      PH-like; Pleckstrin homology-like domain

    4. XM_006512372.4 → XP_006512435.1  oxysterol-binding protein-related protein 10 isoform X4

      See identical proteins and their annotated locations for XP_006512435.1

      UniProtKB/TrEMBL
      A0A0R4J0F9, S4R296
      Conserved Domains (2) summary
      pfam01237
      Location:265 → 625
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1 → 46
      PH-like; Pleckstrin homology-like domain

    5. XM_006512373.5 → XP_006512436.1  oxysterol-binding protein-related protein 10 isoform X4

      See identical proteins and their annotated locations for XP_006512436.1

      UniProtKB/TrEMBL
      A0A0R4J0F9, S4R296
      Related
      ENSMUSP00000138552.2, ENSMUST00000182384.8
      Conserved Domains (2) summary
      pfam01237
      Location:265 → 625
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1 → 46
      PH-like; Pleckstrin homology-like domain

    6. XM_011243051.4 → XP_011241353.1  oxysterol-binding protein-related protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J0F9
      Conserved Domains (2) summary
      pfam01237
      Location:346 → 706
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:37 → 127
      PH-like; Pleckstrin homology-like domain

    7. XM_006512374.3 → XP_006512437.1  oxysterol-binding protein-related protein 10 isoform X5

      UniProtKB/TrEMBL
      A0A0R4J0F9
      Conserved Domains (1) summary
      pfam01237
      Location:264 → 624
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_036155361.1 → XP_036011254.1  oxysterol-binding protein-related protein 10 isoform X6

      UniProtKB/TrEMBL
      A0A0R4J0F9
      Conserved Domains (1) summary
      pfam01237
      Location:200 → 560
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_006512376.5 → XP_006512439.1  oxysterol-binding protein-related protein 10 isoform X7

      Conserved Domains (1) summary
      pfam01237
      Location:118 → 478
      Oxysterol_BP; Oxysterol-binding protein

    RNA

    1. XR_003948042.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176901.2: Suppressed sequence

      Description
      NM_176901.2: This RefSeq was removed because the transcript is partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    S4R1M9.1 GenPept UniProtKB/Swiss-Prot:S4R1M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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