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    Ccdc62 coiled-coil domain containing 62 [ Mus musculus (house mouse) ]

    Gene ID: 208908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc62provided by MGI
    Official Full Name
    coiled-coil domain containing 62provided by MGI
    Primary source
    MGI:MGI:2684996
    See related
    Ensembl:ENSMUSG00000061882 AllianceGenome:MGI:2684996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm150; repro29; G1-485-3
    Summary
    Predicted to enable nuclear estrogen receptor binding activity and nuclear receptor coactivator activity. Involved in spermatid development. Acts upstream of or within blastocyst hatching. Located in acrosomal vesicle. Is expressed in early conceptus and secondary oocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 67. Orthologous to human CCDC62 (coiled-coil domain containing 62). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 17.0), bladder adult (RPKM 2.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc62 in Genome Data Viewer
    Location:
    5 F; 5 63.28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124068683..124107958)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123930425..123969895)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydrocarboxylic acid receptor 1 Neighboring gene STARR-seq mESC enhancer starr_14329 Neighboring gene STARR-positive B cell enhancer ABC_E4789 Neighboring gene density-regulated protein Neighboring gene STARR-positive B cell enhancer ABC_E6379 Neighboring gene STARR-seq mESC enhancer starr_14330 Neighboring gene STARR-positive B cell enhancer mm9_chr5:124397405-124397706 Neighboring gene STARR-positive B cell enhancer ABC_E6380 Neighboring gene STARR-positive B cell enhancer ABC_E1689 Neighboring gene predicted gene, 46922 Neighboring gene huntingtin interacting protein 1 related Neighboring gene microRNA 7032

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice. Li Y, et al. Biol Reprod, 2017 Mar 1. PMID 28339613
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. required for maintenance for normal spermiogenesis and male fertility
      Title: A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134767.1 → NP_001128239.1  coiled-coil domain-containing protein 62

      See identical proteins and their annotated locations for NP_001128239.1

      Status: VALIDATED

      Source sequence(s)
      AC122753
      Consensus CDS
      CCDS51646.1
      UniProtKB/Swiss-Prot
      E9PVD1, F6WEA5
      Related
      ENSMUSP00000091878.4, ENSMUST00000094320.11
      Conserved Domains (1) summary
      COG1196
      Location:57 → 353
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124068683..124107958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530268.4 → XP_006530331.1  coiled-coil domain-containing protein 62 isoform X10

      See identical proteins and their annotated locations for XP_006530331.1

      Conserved Domains (1) summary
      COG1196
      Location:65 → 330
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_030254332.2 → XP_030110192.1  coiled-coil domain-containing protein 62 isoform X13

      Conserved Domains (1) summary
      COG1196
      Location:53 → 312
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006530269.4 → XP_006530332.1  coiled-coil domain-containing protein 62 isoform X10

      See identical proteins and their annotated locations for XP_006530332.1

      Conserved Domains (1) summary
      COG1196
      Location:65 → 330
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_006530266.5 → XP_006530329.1  coiled-coil domain-containing protein 62 isoform X9

      Conserved Domains (1) summary
      COG1196
      Location:65 → 330
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_006530271.5 → XP_006530334.1  coiled-coil domain-containing protein 62 isoform X11

      Conserved Domains (1) summary
      COG1196
      Location:57 → 330
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_006530273.4 → XP_006530336.1  coiled-coil domain-containing protein 62 isoform X12

      See identical proteins and their annotated locations for XP_006530336.1

      Conserved Domains (1) summary
      COG1196
      Location:57 → 330
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006530274.4 → XP_006530337.1  coiled-coil domain-containing protein 62 isoform X12

      See identical proteins and their annotated locations for XP_006530337.1

      Conserved Domains (1) summary
      COG1196
      Location:57 → 330
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_006530260.5 → XP_006530323.1  coiled-coil domain-containing protein 62 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:57 → 353
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. XM_017320780.3 → XP_017176269.1  coiled-coil domain-containing protein 62 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:57 → 353
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. XM_006530255.5 → XP_006530318.1  coiled-coil domain-containing protein 62 isoform X1

      See identical proteins and their annotated locations for XP_006530318.1

      UniProtKB/Swiss-Prot
      E9PVD1, F6WEA5
      Conserved Domains (1) summary
      COG1196
      Location:57 → 353
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_006530258.5 → XP_006530321.1  coiled-coil domain-containing protein 62 isoform X3

      Conserved Domains (1) summary
      TIGR02168
      Location:39 → 344
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_036164964.1 → XP_036020857.1  coiled-coil domain-containing protein 62 isoform X1

      UniProtKB/Swiss-Prot
      E9PVD1, F6WEA5
      Conserved Domains (1) summary
      COG1196
      Location:57 → 353
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    13. XM_006530261.5 → XP_006530324.1  coiled-coil domain-containing protein 62 isoform X6

      Conserved Domains (1) summary
      COG1196
      Location:95 → 353
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. XM_006530257.5 → XP_006530320.1  coiled-coil domain-containing protein 62 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:52 → 335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    15. XM_006530259.5 → XP_006530322.1  coiled-coil domain-containing protein 62 isoform X4

      Conserved Domains (1) summary
      COG1196
      Location:59 → 319
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    16. XM_030254331.1 → XP_030110191.1  coiled-coil domain-containing protein 62 isoform X7

      Conserved Domains (1) summary
      COG1196
      Location:42 → 150
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    17. XM_006530263.5 → XP_006530326.1  coiled-coil domain-containing protein 62 isoform X8

    RNA

    1. XR_001784651.3 RNA Sequence

    2. XR_001784652.3 RNA Sequence

    3. XR_004942476.1 RNA Sequence

    4. XR_001784655.3 RNA Sequence

    5. XR_001784654.3 RNA Sequence

    6. XR_001784653.3 RNA Sequence

    7. XR_003955611.2 RNA Sequence

    8. XR_001784649.3 RNA Sequence

    9. XR_387558.5 RNA Sequence

    10. XR_001784650.3 RNA Sequence

    11. XR_004942475.1 RNA Sequence

    12. XR_003955610.2 RNA Sequence

    13. XR_001784648.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PVD1.1 GenPept UniProtKB/Swiss-Prot:E9PVD1

    Gene LinkOut

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