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    Bmp2 bone morphogenetic protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 12156, updated on 4-Jan-2025

    Summary

    Official Symbol
    Bmp2provided by MGI
    Official Full Name
    bone morphogenetic protein 2provided by MGI
    Primary source
    MGI:MGI:88177
    See related
    Ensembl:ENSMUSG00000027358 AllianceGenome:MGI:88177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmp2a
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. While a homozygous knockout mouse for this gene exhibits embryonic lethality, conditional knockout mice have defects in bone, cartilage and heart development. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in colon adult (RPKM 19.7), stomach adult (RPKM 14.3) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Bmp2 in Genome Data Viewer
    Location:
    2 F2; 2 65.21 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (133394079..133404816)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (133552159..133562896)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430048G15 gene Neighboring gene STARR-seq mESC enhancer starr_05762 Neighboring gene predicted gene 14100 Neighboring gene Bmp2 5' regulatory region Neighboring gene microRNA 3090 Neighboring gene predicted gene, 25258

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP receptor binding PubMed 
    enables co-receptor binding  
    enables co-receptor binding  
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables growth factor activity  
    enables growth factor activity  
    enables identical protein binding  
    enables phosphatase activator activity PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein serine/threonine kinase activator activity PubMed 
    enables protein serine/threonine kinase activator activity  
    enables receptor ligand activity PubMed 
    Items 1 - 25 of 172
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway PubMed 
    involved_in BMP signaling pathway PubMed 
    acts_upstream_of_or_within BMP signaling pathway PubMed 
    involved_in BMP signaling pathway PubMed 
    acts_upstream_of_or_within BMP signaling pathway PubMed 
    involved_in BMP signaling pathway  
    acts_upstream_of_or_within Notch signaling pathway PubMed 
    acts_upstream_of ameloblast differentiation PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of_or_within aortic valve development PubMed 
    acts_upstream_of astrocyte differentiation PubMed 
    acts_upstream_of astrocyte differentiation PubMed 
    involved_in atrioventricular canal morphogenesis PubMed 
    acts_upstream_of_or_within atrioventricular valve morphogenesis PubMed 
    involved_in bone development PubMed 
    acts_upstream_of_or_within bone mineralization PubMed 
    acts_upstream_of_or_within bone mineralization PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
    involved_in cardiac atrium formation PubMed 
    involved_in cardiac epithelial to mesenchymal transition  
    involved_in cardiac epithelial to mesenchymal transition  
    involved_in cardiac jelly development PubMed 
    involved_in cardiac muscle cell differentiation PubMed 
    involved_in cardiac muscle cell differentiation  
    involved_in cardiac muscle cell differentiation  
    involved_in cardiac muscle hypertrophy in response to stress  
    acts_upstream_of_or_within cardiac muscle tissue morphogenesis PubMed 
    acts_upstream_of_or_within cardiocyte differentiation PubMed 
    involved_in cardiocyte differentiation  
    acts_upstream_of_or_within cell fate commitment PubMed 
    involved_in cellular response to BMP stimulus  
    acts_upstream_of_or_within cellular response to growth factor stimulus PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
    involved_in chondrocyte differentiation  
    involved_in chondrocyte differentiation  
    acts_upstream_of_or_within corticotropin hormone secreting cell differentiation PubMed 
    acts_upstream_of_or_within embryo development PubMed 
    acts_upstream_of_or_within embryonic heart tube anterior/posterior pattern specification PubMed 
    involved_in endocardial cushion formation PubMed 
    acts_upstream_of_or_within endocardial cushion morphogenesis PubMed 
    involved_in endocardial cushion morphogenesis PubMed 
    involved_in endodermal-mesodermal cell signaling  
    involved_in endodermal-mesodermal cell signaling  
    involved_in epithelial to mesenchymal transition PubMed 
    acts_upstream_of_or_within epithelial to mesenchymal transition PubMed 
    involved_in epithelial to mesenchymal transition  
    involved_in gene expression PubMed 
    acts_upstream_of_or_within heart development PubMed 
    involved_in heart development  
    involved_in heart induction  
    involved_in heart induction  
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in inflammatory response PubMed 
    acts_upstream_of_or_within inner ear development PubMed 
    involved_in lung vasculature development  
    involved_in lung vasculature development  
    involved_in mesenchymal cell differentiation  
    involved_in mesenchymal cell differentiation  
    involved_in mesenchymal cell proliferation involved in ureteric bud development PubMed 
    involved_in mesenchyme development  
    involved_in mesenchyme development  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of negative regulation of MAP kinase activity  
    involved_in negative regulation of aldosterone biosynthetic process  
    involved_in negative regulation of aldosterone biosynthetic process  
    involved_in negative regulation of calcium-independent cell-cell adhesion  
    involved_in negative regulation of calcium-independent cell-cell adhesion  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cardiac muscle cell differentiation  
    involved_in negative regulation of cardiac muscle cell differentiation  
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell cycle  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cortisol biosynthetic process  
    involved_in negative regulation of cortisol biosynthetic process  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    acts_upstream_of_or_within negative regulation of gene expression PubMed 
    acts_upstream_of negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway  
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway  
    involved_in negative regulation of muscle cell differentiation PubMed 
    involved_in negative regulation of smooth muscle cell proliferation PubMed 
    involved_in negative regulation of smooth muscle cell proliferation  
    involved_in negative regulation of steroid biosynthetic process  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within osteoblast differentiation PubMed 
    involved_in osteoblast differentiation PubMed 
    acts_upstream_of_or_within osteoblast differentiation PubMed 
    acts_upstream_of_or_within osteoblast differentiation  
    involved_in osteoblast differentiation  
    involved_in osteoclast differentiation  
    involved_in osteoclast differentiation  
    acts_upstream_of_or_within pericardium development PubMed 
    acts_upstream_of positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of positive regulation of SMAD protein signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of SMAD protein signal transduction  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway PubMed 
    involved_in positive regulation of Wnt signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of astrocyte differentiation PubMed 
    acts_upstream_of_or_within positive regulation of astrocyte differentiation PubMed 
    involved_in positive regulation of bone mineralization PubMed 
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of bone mineralization involved in bone maturation  
    involved_in positive regulation of bone mineralization involved in bone maturation  
    acts_upstream_of_or_within positive regulation of cartilage development PubMed 
    acts_upstream_of_or_within positive regulation of cartilage development PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of extracellular matrix constituent secretion PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation PubMed 
    acts_upstream_of positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    acts_upstream_of positive regulation of gene expression PubMed 
    acts_upstream_of positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of miRNA transcription PubMed 
    acts_upstream_of_or_within positive regulation of neurogenesis PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation PubMed 
    involved_in positive regulation of odontoblast differentiation PubMed 
    acts_upstream_of_or_within positive regulation of odontogenesis PubMed 
    acts_upstream_of_or_within positive regulation of ossification PubMed 
    acts_upstream_of_or_within positive regulation of ossification PubMed 
    acts_upstream_of_or_within positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of osteoblast proliferation PubMed 
    involved_in positive regulation of p38MAPK cascade  
    involved_in positive regulation of p38MAPK cascade  
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway  
    acts_upstream_of_or_within positive regulation of peroxisome proliferator activated receptor signaling pathway  
    acts_upstream_of_or_within positive regulation of phosphatase activity PubMed 
    involved_in positive regulation of protein binding  
    acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of protein phosphorylation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within protein destabilization PubMed 
    acts_upstream_of_or_within protein destabilization PubMed 
    acts_upstream_of_or_within proteoglycan metabolic process PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within response to bacterium PubMed 
    acts_upstream_of_or_within response to hypoxia PubMed 
    acts_upstream_of_or_within telencephalon development PubMed 
    acts_upstream_of_or_within telencephalon regionalization PubMed 
    acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway PubMed 
    Items 1 - 25 of 172
    Component Evidence Code Pubs
    part_of BMP receptor complex  
    part_of BMP receptor complex  
    located_in cell surface  
    located_in cell surface  
    is_active_in extracellular region PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    is_active_in plasma membrane PubMed 
    part_of protein-containing complex  
    located_in vesicle  

    General protein information

    Preferred Names
    bone morphogenetic protein 2
    Names
    bone morphogenetic protein 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007553.3NP_031579.2  bone morphogenetic protein 2 preproprotein

      See identical proteins and their annotated locations for NP_031579.2

      Status: REVIEWED

      Source sequence(s)
      AK133923, AK161862, AV333272, BC100344
      Consensus CDS
      CCDS16782.1
      UniProtKB/Swiss-Prot
      P21274, Q497W8
      UniProtKB/TrEMBL
      Q3V1I4
      Related
      ENSMUSP00000028836.7, ENSMUST00000028836.7
      Conserved Domains (2) summary
      smart00204
      Location:294394
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:43265
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      133394079..133404816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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