Cnot6l CCR4-NOT transcription complex, subunit 6-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnot6lprovided by MGI
Official Full Name: CCR4-NOT transcription complex, subunit 6-likeprovided by MGI
Primary source: MGI:MGI:2443154
See related: Ensembl:ENSMUSG00000034724 AllianceGenome:MGI:2443154
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4932442K20Rik
Summary: Enables poly(A)-specific ribonuclease activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and musculature. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E3; 5 47.29 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (96218192..96312044, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (96070333..96164198, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High expression of CNOT6L contributes to the negative development of type 2 diabetes.
Title: High expression of CNOT6L contributes to the negative development of type 2 diabetes.
Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
Title: Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.
Title: CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.
FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development.
Title: FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development.
Loss of Cnot6l Impairs Inosine RNA Modifications in Mouse Oocytes.
Title: Loss of Cnot6l Impairs Inosine RNA Modifications in Mouse Oocytes.
This study provides the first direct genetic evidence that CCR4-NOT-dependent and particularly CNOT6L-dependent decay of selective maternal mRNAs is a prerequisite for meiotic maturation of oocytes.
Title: CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte.
Using the 3'-UTRs of mouse Cpeb1, Btg4 and Cnot6l mRNAs, we deciphered the combinatorial code that controls developmental stage-specific translation during meiotic maturation
Title: A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte.
This initial screen isolated two potential Emx2-binding partner proteins, Cnot6l and QkI-7. These novel Emx2-binding proteins are involved in multiple levels of mRNA metabolism that including splicing, mRNA export, translation, and destruction
Title: Identification of Novel Binding Partners for Transcription Factor Emx2.
CCR4b may be involved in various cellular events that include cell proliferation.
Title: Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235227

NoName (e-PCR)
- UniSTS:235228

NoName (e-PCR)
- UniSTS:235229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables poly(A)-specific ribonuclease activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic mRNA processing body assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic mRNA processing body assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	ISO Inferred from Sequence Orthology more info
part_of CCR4-NOT complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 6-like

NP_001272440.1

EC 3.1.13.4

NP_001272443.1

EC 3.1.13.4

NP_659159.1

EC 3.1.13.4

NP_849185.2

EC 3.1.13.4

XP_006534933.1

EC 3.1.13.4

XP_006534934.1

EC 3.1.13.4

XP_006534935.1

EC 3.1.13.4

XP_030110258.1

EC 3.1.13.4

XP_030110259.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285511.1 → NP_001272440.1 CCR4-NOT transcription complex subunit 6-like isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.

Source sequence(s)

AC129600, AK030112, AK151728

Consensus CDS

CCDS19448.1

UniProtKB/Swiss-Prot

Q8VEG6

Conserved Domains (3) summary

cd10312
Location:186 → 533

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:52 → 178

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:33 → 52

LRR_1; leucine-rich repeat [structural motif]
NM_001285514.1 → NP_001272443.1 CCR4-NOT transcription complex subunit 6-like isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 2.

Source sequence(s)

AC129600, AK030112, AK151728

UniProtKB/Swiss-Prot

Q8VEG6

Conserved Domains (2) summary

cd10312
Location:91 → 438

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:3 → 83

LRR; Leucine-rich repeat (LRR) protein [Transcription]
NM_144910.2 → NP_659159.1 CCR4-NOT transcription complex subunit 6-like isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.

Source sequence(s)

AC129600, AK030112, AK151728, BC018506, CF173938

Consensus CDS

CCDS19448.1

UniProtKB/Swiss-Prot

Q8VEG6

Related

ENSMUSP00000119415.2, ENSMUST00000155901.8

Conserved Domains (3) summary

cd10312
Location:186 → 533

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:52 → 178

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:33 → 52

LRR_1; leucine-rich repeat [structural motif]
NM_178854.4 → NP_849185.2 CCR4-NOT transcription complex subunit 6-like isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AC129600, AK030112, AK151728

Consensus CDS

CCDS51566.1

UniProtKB/Swiss-Prot

Q3U9M0, Q8C0P4, Q8VEG6

Related

ENSMUSP00000108629.3, ENSMUST00000113005.9

Conserved Domains (3) summary

cd10312
Location:191 → 538

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:57 → 183

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:38 → 57

LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

96218192..96312044 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534870.5 → XP_006534933.1 CCR4-NOT transcription complex subunit 6-like isoform X1

UniProtKB/Swiss-Prot

Q8VEG6

Conserved Domains (3) summary

cd10312
Location:186 → 533

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:52 → 178

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:33 → 52

LRR_1; leucine-rich repeat [structural motif]
XM_030254398.1 → XP_030110258.1 CCR4-NOT transcription complex subunit 6-like isoform X2

Conserved Domains (2) summary

cd10312
Location:91 → 438

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:3 → 83

LRR; Leucine-rich repeat (LRR) protein [Transcription]
XM_006534871.3 → XP_006534934.1 CCR4-NOT transcription complex subunit 6-like isoform X1

UniProtKB/Swiss-Prot

Q8VEG6

Conserved Domains (3) summary

cd10312
Location:186 → 533

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:52 → 178

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:33 → 52

LRR_1; leucine-rich repeat [structural motif]
XM_030254399.2 → XP_030110259.1 CCR4-NOT transcription complex subunit 6-like isoform X2

Conserved Domains (2) summary

cd10312
Location:91 → 438

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like

COG4886
Location:3 → 83

LRR; Leucine-rich repeat (LRR) protein [Transcription]
XM_006534872.4 → XP_006534935.1 CCR4-NOT transcription complex subunit 6-like isoform X3

Conserved Domains (1) summary

cd10312
Location:50 → 397

Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like