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    Hoatz HOATZ cilia and flagella associated protein [ Mus musculus (house mouse) ]

    Gene ID: 235345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hoatzprovided by MGI
    Official Full Name
    HOATZ cilia and flagella associated proteinprovided by MGI
    Primary source
    MGI:MGI:1921013
    See related
    Ensembl:ENSMUSG00000032057 AllianceGenome:MGI:1921013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hoatzin; 4833427G06Rik
    Summary
    Involved in axoneme assembly; flagellated sperm motility; and spermatogenesis. Located in cilium and cytoplasm. Is expressed in embryo and lung. Orthologous to human HOATZ (HOATZ cilia and flagella associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 20.5) and lung adult (RPKM 1.2) See more
    Orthologs
    human all
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    Genomic context

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    See Hoatz in Genome Data Viewer
    Location:
    9 A5.3; 9 27.81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50992610..51017183, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51081310..51105834, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene STARR-seq mESC enhancer starr_24125 Neighboring gene microRNA 34b Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4 Neighboring gene predicted gene, 32742 Neighboring gene STARR-positive B cell enhancer ABC_E10544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:50973591-50973879 Neighboring gene STARR-seq mESC enhancer starr_24126 Neighboring gene STARR-positive B cell enhancer ABC_E6731 Neighboring gene STARR-positive B cell enhancer ABC_E10545 Neighboring gene STARR-positive B cell enhancer ABC_E6732 Neighboring gene POU domain, class 2, associating factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Carboxyl Terminus of HOATZ is Intrinsically Disordered and Interacts with Heat Shock Protein A Families. Narita K, et al. Protein Pept Lett, 2022. PMID 36098411
    2. Discovery of a Vertebrate-Specific Factor that Processes Flagellar Glycolytic Enolase during Motile Ciliogenesis. Narita K, et al. iScience, 2020 Apr 24. PMID 32248064, Free PMC Article
    3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    5. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC58631

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein HOATZ
    Names
    UPF0722 protein C11orf88 homolog
    protein Hoatz

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177702.4 → NP_808370.1  cilia- and flagella-associated protein HOATZ

      See identical proteins and their annotated locations for NP_808370.1

      Status: PROVISIONAL

      Source sequence(s)
      AC119831
      Consensus CDS
      CCDS40628.1
      UniProtKB/Swiss-Prot
      Q3V0W8, Q80Y73
      UniProtKB/TrEMBL
      Q9D5Z9
      Related
      ENSMUSP00000126725.2, ENSMUST00000170947.3
      Conserved Domains (1) summary
      pfam17664
      Location:1 → 168
      DUF5526; Family of unknown function (DUF5526)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50992610..51017183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244326.2 → XP_030100186.1  cilia- and flagella-associated protein HOATZ isoform X1

      UniProtKB/Swiss-Prot
      Q3V0W8, Q80Y73
      UniProtKB/TrEMBL
      Q9D5Z9
      Conserved Domains (1) summary
      pfam17664
      Location:1 → 168
      DUF5526; Family of unknown function (DUF5526)

    2. XM_030244327.1 → XP_030100187.1  cilia- and flagella-associated protein HOATZ isoform X1

      UniProtKB/Swiss-Prot
      Q3V0W8, Q80Y73
      UniProtKB/TrEMBL
      Q9D5Z9
      Conserved Domains (1) summary
      pfam17664
      Location:1 → 168
      DUF5526; Family of unknown function (DUF5526)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y73.1 GenPept UniProtKB/Swiss-Prot:Q80Y73

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